Kristensen B O, Andersen P L, Lamm L U, Kissmeyer-Nielsen F
Tissue Antigens. 1977 Aug;10(2):70-4.
HLA-typing was performed in 149 patients with essential hypertension, 86 males and 63 females. In 66 patients with significantly elevated serum levels of immunoglobulins, HLA-B27 was increased to 18%, from 8% in the controls (P less than 0.007). This was not significant when correcting the P-value for the number of antigens analyzed, but confirms reports of an association of this antigen with serum levels of immunoglobulins. HLA-Bw15 was found to be increased two-fold in patients with a family history of hypertension (P corrected less than 0.05) and in patients with autoantibodies (not significant). This is discussed in relation to the increase of Bw15 in juvenile diabetes and in Systemic Lupus Erythematosus, diseases in which vascular damage also occurs.
对149例原发性高血压患者进行了HLA分型，其中男性86例，女性63例。在66例血清免疫球蛋白水平显著升高的患者中，HLA - B27从对照组的8%升至18%（P小于0.007）。在校正分析的抗原数量的P值后，这一差异无统计学意义，但证实了该抗原与血清免疫球蛋白水平相关的报道。发现有高血压家族史的患者以及有自身抗体的患者中HLA - Bw15增加了两倍（校正P值小于0.05），有自身抗体的患者中这一差异无统计学意义。结合青少年糖尿病和系统性红斑狼疮中Bw15的增加对此进行了讨论，这两种疾病中也会发生血管损伤。
