急性风湿热中免疫复合物的检测及其与HLA - B5的关系。
Detection of immune complexes in acute rheumatic fever and their relationship to HLA-B5.
作者信息
Yoshinoya S, Pope R M
出版信息
J Clin Invest. 1980 Jan;65(1):136-45. doi: 10.1172/JCI109643.
Employing five radioimmunoassays for immune complexes, the sera of 45 acute and 27 postacute follow-up sera from patients with acute rheumatic fever were examined. All patients experienced actue polyarthritis. Complexes were detected in 89% of acute-phase sera by one assay, 51% by two, 29% by three, and 7% by four. Immune complex values decreased significantly at followup, although some abnormalities persisted. There was no correlation between extra-articular manifestations and the occurrence of circulating immune complexes. Those positive for HLA-B5 demonstrated a significantly more pronounced immune response as measured by circulating immune complexes. The data indicate that circulating immune complexes occur frequently in adults with acute rheumatic fever. The relative frequency of immune complexes detected by multiple techniques in B5-positive, compared with B5-negative, patients suggests a genetic basis for the development of immune complexes in these patiemts.
采用五种免疫复合物放射免疫测定法，对45例急性风湿热患者的急性期血清以及27例急性后期随访血清进行了检测。所有患者均经历了急性多关节炎。通过一种检测方法在89%的急性期血清中检测到复合物，两种检测方法为51%，三种检测方法为29%，四种检测方法为7%。随访时免疫复合物值显著下降，尽管仍有一些异常情况持续存在。关节外表现与循环免疫复合物的出现之间没有相关性。通过循环免疫复合物测量，HLA - B5阳性者表现出明显更显著的免疫反应。数据表明，循环免疫复合物在成人急性风湿热患者中频繁出现。与B5阴性患者相比，通过多种技术在B5阳性患者中检测到免疫复合物的相对频率表明这些患者中免疫复合物的形成存在遗传基础。
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