Milone Marco, De Placido Giuseppe, Musella Mario, Sosa Fernandez Loredana Maria, Sosa Fernandez Laura Virginia, Campana Gabriele, Di Minno Matteo Nicola Dario, Milone Francesco
Department of Advanced Biomedical Science Surgery Unit, University of Naples "Federico II", Via Pansini 5, 80131, Naples, Italy.
Obes Surg. 2016 Feb;26(2):443-51. doi: 10.1007/s11695-015-1998-7.
Little is known about the impact of weight loss interventions on pregnancy rate. A systematic review with meta-analysis of literature has been performed to evaluate the incidence of successful pregnancy after bariatric interventions in infertile women. By pooling together data from 589 infertile obese women, we have been able to provide an aggregate estimation of successful pregnancy after weight loss interventions. Our results showed an impressive high incidence (58%) of infertile women who become spontaneously pregnant after surgery. Based on our results, bariatric interventions could be included in the treatment of obesity-related infertility. However, the results must be interpreted with caution owning to the quality of the data provided by included studies. Further ad hoc studies are needed to validate the effectiveness of bariatric interventions on reproductive function.
关于减肥干预措施对妊娠率的影响，目前所知甚少。我们进行了一项系统性综述并对文献进行荟萃分析，以评估减肥手术后不孕女性成功妊娠的发生率。通过汇总589名肥胖不孕女性的数据，我们得以对减肥干预措施后的成功妊娠情况进行总体估计。我们的结果显示，术后自然受孕的不孕女性发生率高达58%，令人印象深刻。基于我们的结果，减肥干预措施可纳入肥胖相关不孕症的治疗。然而，由于纳入研究提供的数据质量问题，对结果的解读必须谨慎。需要进一步开展专门研究来验证减肥干预措施对生殖功能的有效性。
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