Cooper Zara, Mitchell Susan L, Gorges Rebecca J, Rosenthal Ronnie A, Lipsitz Stuart R, Kelley Amy S
Department of Surgery, Brigham and Women's Hospital, Boston, Massachusetts.
Center for Surgery and Public Health, Brigham and Women's Hospital, Boston, Massachusetts.
J Am Geriatr Soc. 2015 Dec;63(12):2572-2579. doi: 10.1111/jgs.13785. Epub 2015 Dec 11.
To identify factors associated with mortality in older adults 30, 180, and 365 days after emergency major abdominal surgery.
A retrospective study linked to Medicare claims from 2000 to 2010.
Health and Retirement Study (HRS).
Medicare beneficiaries aged 65.5 enrolled in the HRS from 2000 to 2010 with at least one urgent or emergency major abdominal surgery and a core interview from the HRS within 3 years before surgery.
Survival analysis was used to describe all-cause mortality 30, 180, and 365 days after surgery. Complementary log-log regression was used to identify participant characteristics and postoperative events associated with poorer survival.
Four hundred individuals had one of the urgent or emergency surgeries of interest, 24% of whom were aged 85 and older, 50% had coronary artery disease, 48% had cancer, 33% had congestive heart failure, and 37% experienced a postoperative complication. Postoperative mortality was 20% at 30 days, 31% at 180 days, and 34% at 365 days. Of those aged 85 and older, 50% were dead 1 year after surgery. After multivariate adjustment including postoperative complications, dementia (hazard ratio (HR) = 2.02, 95% confidence interval (CI) = 1.24-3.31), hospitalization within 6 months before surgery (HR = 1.63, 95% CI = 1.12-2.28), and complications (HR = 3.45, 95% CI = 2.32-5.13) were independently associated with worse 1-year survival.
Overall mortality is high in many older adults up to 1 year after undergoing emergency major abdominal surgery. The occurrence of a complication is the clinical factor most strongly associated with worse survival.
确定老年患者在急诊大腹部手术后30天、180天和365天与死亡相关的因素。
一项与2000年至2010年医疗保险索赔相关的回顾性研究。
健康与退休研究(HRS)。
2000年至2010年参加HRS的65.5岁医疗保险受益人,至少接受过一次紧急或急诊大腹部手术,且在手术前3年内接受过HRS的核心访谈。
生存分析用于描述术后30天、180天和365天的全因死亡率。互补对数-对数回归用于确定与较差生存相关的参与者特征和术后事件。
400人接受了一项感兴趣的紧急或急诊手术,其中24%年龄在85岁及以上,50%患有冠状动脉疾病,48%患有癌症,33%患有充血性心力衰竭,37%经历了术后并发症。术后30天死亡率为20%,180天为31%,365天为34%。85岁及以上的患者中,50%在术后1年死亡。在包括术后并发症在内的多变量调整后,痴呆(风险比(HR)=2.02,95%置信区间(CI)=1.24-3.31)、手术前6个月内住院(HR=1.63,95%CI=1.12-2.28)和并发症(HR=3.45,95%CI=2.32-5.13)与较差的1年生存率独立相关。
许多老年患者在接受急诊大腹部手术后1年内总体死亡率较高。并发症的发生是与较差生存最密切相关的临床因素。