Wang L F, Ding Y J, Zhao Q, Zhang X L
Department of Rheumatology, Huaihe Hospital of Henan University, Kaifeng, China.
Department of Nephropathy Rheumatology, Third Affiliated Hospital of Xinxiang Medical University, Xinxiang, China.
Genet Mol Res. 2015 Dec 9;14(4):16410-4. doi: 10.4238/2015.December.9.10.
We conducted a case-control study to investigate the association between 3 common NALP3 polymorphisms (rs10754558, rs7512998, and rs12137901) and the susceptibility to primary gout. A total of 320 patients with primary gout and 320 controls were included in this study. The genotyping of NALP3 rs10754558, rs7512998, and rs12137901 were conducted by polymerase chain reaction-restriction fragment length polymorphism. Comparison analysis showed that primary gout patients were more likely to have higher body mass index, prevalence of hypertension, blood glucose, triglycerides, urea nitrogen, and uric acid (P < 0.05). Logistic regression analysis revealed no significant association between the NALP3 rs10754558, rs7512998, and rs12137901 polymorphisms and the risk of gouty arthritis. In conclusion, we found no significant association between NALP3 gene polymorphisms and the risk of primary gout.
我们进行了一项病例对照研究，以调查3种常见的NALP3基因多态性（rs10754558、rs7512998和rs12137901）与原发性痛风易感性之间的关联。本研究共纳入320例原发性痛风患者和320例对照。通过聚合酶链反应-限制性片段长度多态性对NALP3 rs10754558、rs7512998和rs12137901进行基因分型。比较分析表明，原发性痛风患者更有可能具有较高的体重指数、高血压患病率、血糖、甘油三酯、尿素氮和尿酸（P<0.05）。逻辑回归分析显示，NALP3 rs10754558、rs7512998和rs12137901基因多态性与痛风性关节炎风险之间无显著关联。总之，我们发现NALP3基因多态性与原发性痛风风险之间无显著关联。
