百里醌和橄榄苦苷对链脲佐菌素诱导的实验性动物糖尿病的降血糖作用。
Antihyperglycemic effect of thymoquinone and oleuropein, on streptozotocin-induced diabetes mellitus in experimental animals.
作者信息
Sangi Sibghatullah Muhammad Ali, Sulaiman Mansour Ibrahim, El-Wahab Mohammed Fawzy Abd, Ahmedani Elsamoual Ibrahim, Ali Soad Shaker
机构信息
Department of Clinical Pharmacy, College of Pharmacy, Northern Borders University, Rafha, Kingdom of Saudi Arabia.
King Fahad Medical Research center, Faculty of Medicine, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia.
出版信息
Pharmacogn Mag. 2015 Oct;11(Suppl 2):S251-7. doi: 10.4103/0973-1296.166017.
BACKGROUND
Diabetes mellitus is one of the most important diseases related with endocrines. Its main manifestation includes abnormal metabolism of carbohydrates and lipids and inappropriate hyperglycemia that is caused by absolute or relative insulin deficiency. It affects humankind worldwide.
OBJECTIVES
Our research was aimed to observe antihyperglycemic activity of thymoquinone and oleuropein.
MATERIALS AND METHODS
In this study, rats were divided into six groups, 6 rats in each. Diabetes was inducted by streptozotocin (STZ). The level of fasting blood glucose was determined for each rats during the experiment, doses of thymoquinone and oleuropein (3 mg/kg and 5 mg/kg) for both, were injected intraperitoneal. Pancreatic tissues were investigated to compare β-cells in diabetic and treated rats.
RESULT AND CONCLUSION
It was found that thymoquinone and oleuropein significantly decrease serum Glucose levels in STZ induced diabetic rats.
背景
糖尿病是最重要的内分泌相关疾病之一。其主要表现包括碳水化合物和脂质代谢异常以及由绝对或相对胰岛素缺乏引起的不适当高血糖。它影响着全世界的人类。
目的
我们的研究旨在观察百里醌和橄榄苦苷的降血糖活性。
材料与方法
在本研究中，将大鼠分为六组，每组6只。通过链脲佐菌素（STZ）诱导糖尿病。在实验期间测定每只大鼠的空腹血糖水平，腹腔注射百里醌和橄榄苦苷的剂量均为（3毫克/千克和5毫克/千克）。对胰腺组织进行研究，以比较糖尿病大鼠和治疗大鼠的β细胞。
结果与结论
发现百里醌和橄榄苦苷可显著降低STZ诱导的糖尿病大鼠的血清葡萄糖水平。
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