Service of Obstetrics and Gynecology, Hospital Clínico Universitario-INCLIVA, Av Blasco Ibáñez 17, 46010 Valencia, Spain.
Department of Genetics, Faculty of Biological Sciences, University of Valencia, Burjassot, and INCLIVA, Av Blasco Ibáñez 17, 46010 Valencia, Spain.
Nutrients. 2020 Oct 18;12(10):3184. doi: 10.3390/nu12103184.
The rates of metabolic syndrome are increasing in parallel with the increasing prevalence of obesity, primarily due to its concomitant insulin resistance. This is particularly concerning for women, as the years around menopause are accompanied by an increase in visceral obesity, a strong determinant of insulin resistance. A fall in estrogens and increase in the androgen/estrogen ratio is attributed a determining role in this process, which has been confirmed in other physiological models, such as polycystic ovary syndrome. A healthy lifestyle, with special emphasis on nutrition, has been recommended as a first-line strategy in consensuses and guidelines. A consistent body of evidence has accumulated suggesting that the Mediterranean diet, with olive oil as a vital component, has both health benefits and acceptable adherence. Herein, we provide an updated overview of current knowledge on the benefits of olive oil most relevant to menopause-associated metabolic syndrome, including an analysis of the components with the greatest health impact, their effect on basic mechanisms of disease, and the state of the art regarding their action on the main features of metabolic syndrome.
代谢综合征的发病率与肥胖症的患病率呈平行上升趋势，主要原因是其伴随的胰岛素抵抗。这对女性来说尤其令人担忧，因为绝经前后的几年伴随着内脏肥胖的增加，而内脏肥胖是胰岛素抵抗的一个重要决定因素。雌激素的下降和雄激素/雌激素比值的增加被认为在这个过程中起决定性作用，这在其他生理模型中得到了证实，如多囊卵巢综合征。健康的生活方式，特别强调营养，已被推荐作为共识和指南中的一线策略。大量证据表明，以橄榄油为重要组成部分的地中海饮食既有益健康，又易于坚持。在此，我们提供了对与绝经相关的代谢综合征最相关的橄榄油益处的最新知识概述，包括对具有最大健康影响的成分的分析，它们对疾病基本机制的影响，以及关于它们对代谢综合征主要特征的作用的最新进展。
