Hassan Abeer, Tsuda Yasuhiro, Asai Akira, Yokohama Keisuke, Nakamura Ken, Sujishi Tetsuya, Ohama Hideko, Tsuchimoto Yusuke, Fukunishi Shinya, Abdelaal Usama M, Arafa Usama A, Hassan Ali T, Kassem Ali M, Higuchi Kazuhide
Second Department of Internal Medicine, Osaka Medical College, 2-7 Daigakumachi, Takatsuki, Osaka 569-8686, Japan ; Department of Internal Medicine, Sohag Faculty of Medicine, Sohag University, Sohag 82524, Egypt.
Second Department of Internal Medicine, Osaka Medical College, 2-7 Daigakumachi, Takatsuki, Osaka 569-8686, Japan.
Mediators Inflamm. 2015;2015:608216. doi: 10.1155/2015/608216. Epub 2015 Nov 19.
Transarterial chemoembolization (TACE) is usually followed by hepatic dysfunction. We evaluated the effects of L-carnitine on post-TACE impaired liver functions. Methods. 53 cirrhotic hepatocellular carcinoma patients at Osaka Medical College were enrolled in this study and assigned into either L-carnitine group receiving 600 mg oral L-carnitine daily or control group. Liver functions were evaluated at pre-TACE and 1, 4, and 12 weeks after TACE. Results. The L-carnitine group maintained Child-Pugh (CP) score at 1 week after TACE and exhibited significant improvement at 4 weeks after TACE (P < 0.01). Conversely, the control group reported a significant CP score deterioration at 1 week (P < 0.05) and 12 weeks after TACE (P < 0.05). L-carnitine suppressed serum albumin deterioration at 1 week after TACE. There were significant differences between L-carnitine and control groups regarding mean serum albumin changes from baseline to 1 week (P < 0.05) and 4 weeks after TACE (P < 0.05). L-carnitine caused prothrombin time improvement from baseline to 1, 4 (P < 0.05), and 12 weeks after TACE. Total bilirubin mean changes from baseline to 1 week after TACE exhibited significant differences between L-carnitine and control groups (P < 0.05). The hepatoprotective effects of L-carnitine were enhanced by branched chain amino acids combination. Conclusion. L-carnitine maintained and improved liver functions after TACE.
经动脉化疗栓塞术（TACE）后通常会出现肝功能障碍。我们评估了左旋肉碱对TACE术后肝功能受损的影响。方法。大阪医科大学的53例肝硬化肝细胞癌患者纳入本研究，分为每日口服600mg左旋肉碱的左旋肉碱组或对照组。在TACE术前以及TACE术后1周、4周和12周评估肝功能。结果。左旋肉碱组在TACE术后1周维持Child-Pugh（CP）评分，并在TACE术后4周表现出显著改善（P<0.01）。相反，对照组在TACE术后1周（P<0.05）和12周（P<0.05）报告CP评分显著恶化。左旋肉碱在TACE术后1周抑制血清白蛋白恶化。左旋肉碱组与对照组从基线到1周以及TACE术后4周的平均血清白蛋白变化存在显著差异（P<0.05）。左旋肉碱使凝血酶原时间从基线到TACE术后1周、4周（P<0.05）和12周有所改善。TACE术后1周从基线开始的总胆红素平均变化在左旋肉碱组与对照组之间存在显著差异（P<0.05）。左旋肉碱与支链氨基酸联合使用可增强其肝脏保护作用。结论。左旋肉碱在TACE术后维持并改善了肝功能。
