Pop C, Calagiu D, Jantea P, Nemes R
"Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania ; Medical Clinic and Gastroenterology, University Emergency Hospital, Bucharest, Romania.
Medical Clinic and Gastroenterology, University Emergency Hospital, Bucharest, Romania.
J Med Life. 2015 Oct-Dec;8(4):492-5.
A 52-year-old woman with Crohn's disease presented with septic arthrtis of the knee. This condition coincided with a symptomatic flare of her Crohn's disease due to an ileal inflammatory stenosis, manifested as a phlegmonous mass palpable in the right lower quadrant and a small bowel obstruction. Results of synovial fluid cultures showed the presence of Gram-negative bacillus, Klebsiella pneumoniae and the CT scan images were highly suggestive of abdominal abscess within Crohn's disease. The patient's condition improved after following an antibiotic treatment and after the initiation of Anti-TNF-alpha agent Adalimumab, with no further exacerbation. Septic arthritis in Crohn's disease should be considered to have a communicating source of sepsis consisting of an abdominal abscess or fistula.
Anti-TNF-alpha agent = anti tumor necrosis factor alpha agent, 5-ASA = 5-aminosalicylic acid.
一名52岁患有克罗恩病的女性出现膝关节化脓性关节炎。这种情况与她因回肠炎性狭窄导致的克罗恩病症状发作同时出现，表现为右下腹可触及的蜂窝织炎肿块和小肠梗阻。滑膜液培养结果显示存在革兰氏阴性杆菌肺炎克雷伯菌，CT扫描图像高度提示克罗恩病合并腹部脓肿。在接受抗生素治疗并开始使用抗TNF-α药物阿达木单抗后，患者的病情有所改善，未再进一步恶化。克罗恩病中的化脓性关节炎应被视为有由腹部脓肿或瘘管组成的败血症传播源。
抗TNF-α药物 = 抗肿瘤坏死因子α药物，5-ASA = 5-氨基水杨酸
