Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, The Netherlands.
Gut. 2011 Oct;60(10):1426-35. doi: 10.1136/gut.2010.228866. Epub 2011 May 6.
Arthropathies are a major clinical problem in patients with inflammatory bowel disease (IBD). Often it is difficult to control the articular symptoms with the anti-inflammatory strategies used for IBD. Studies evaluating specific treatments aimed at articular manifestations in patients with IBD are rare. Although there has been considerable interest in the gut-joint axis over the last decade, the pathophysiological mechanisms driving IBD-associated arthropathy are still unknown. Recently, interest in the multidisciplinary approach to patients with IBD and arthropathy has been increasing. New research and clinical projects aimed at understanding the mechanisms of disease may advance the development of effective therapies. In this review, the pathophysiology of IBD-associated arthropathy is discussed, as well as clinical manifestations, the classification and current therapeutic strategies.
关节病是炎症性肠病（IBD）患者的一个主要临床问题。通常，使用治疗 IBD 的抗炎策略很难控制关节症状。评估针对 IBD 患者关节表现的特定治疗的研究很少。尽管在过去十年中人们对肠道-关节轴非常感兴趣，但驱动 IBD 相关关节病的病理生理机制仍不清楚。最近，人们对患有 IBD 和关节病的患者的多学科方法越来越感兴趣。旨在了解疾病机制的新研究和临床项目可能会促进有效治疗方法的发展。在这篇综述中，讨论了与 IBD 相关的关节病的病理生理学，以及临床表现、分类和当前的治疗策略。
