Grigorescu R, Gruia M I, Nacea V, Nitu C, Negoita V, Glavan D
"Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
"Prof. Dr. Alex. Trestioreanu" Oncological Institute, Bucharest, Romania.
J Med Life. 2015 Oct-Dec;8(4):513-6.
Active oxygen species are produced as a consequence of normal aerobic metabolism. Of these, free radicals are usually metabolized or inactivated in vivo by a team of antioxidants. Individual members are a trained team fighting antioxidants to prevent the generation of ROS, destroy or oxidizing potential of capture. In terms of physiological oxidative stress, induced tissue attack is minimal. A relative or absolute deficiency in the antioxidant defense may lead to increased oxidative stress and this event is associated with both the causes and consequences of diseases and cancer, included here. The aim of the study is to identify the role of antioxidant defense systems and the reduction of oxidative stress in dynamic growth and development of malignant tumors. Our in vivo study was developed and referred to carcinosarcoma carriers Wistar rats treated with non-enzymatic antioxidants: vitamin C, vitamin A, zinc salt (II), and arginine in various combinations. Treatment was initiated three weeks before tumor induction.
活性氧物种是正常有氧代谢的产物。其中，自由基通常在体内被一组抗氧化剂代谢或失活。各个成员就像一支训练有素的团队，对抗氧化物质，以防止活性氧的产生，破坏或捕获氧化潜能。就生理氧化应激而言，诱导的组织损伤极小。抗氧化防御的相对或绝对缺乏可能导致氧化应激增加，而这一事件与疾病和癌症的病因及后果均相关，本文也涵盖了这方面内容。本研究的目的是确定抗氧化防御系统在恶性肿瘤动态生长和发展中的作用以及氧化应激的减轻情况。我们的体内研究是针对用非酶抗氧化剂（维生素C、维生素A、锌盐（II）和精氨酸的各种组合）治疗的Wistar大鼠癌肉瘤携带者开展的。治疗在肿瘤诱导前三周开始。
