Piriu G, Torac E, Gaman L E, Iosif L, Tivig I C, Delia C, Gilca M, Stoian I, Atanasiu V
"Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania ; Sapoca Neuropsychiatry Hospital, Buzau, Romania.
"Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania ; R & D Irist Labmed, Bucharest, Romania.
J Med Life. 2015 Oct-Dec;8(4):548-51.
Estrogens role in schizophrenia patients is a subject, which has gained an increased attention from the medical community. Estrogens have been shown to inhibit dopamine actions, improve neuronal regeneration, and overall, have a protective role in the pathology of schizophrenia. The adjunctive estrogen therapy for men is currently under debate. Antipsychotic medication is known to influence the hypothalamo-hypophyseal - gonadal axis by inducing variable degrees of hyperprolactinemia. Several studies have found that some of the atypical antipsychotics lower cortisol levels in patients and also in healthy controls. We have investigated the effects of clozapine and risperidone on estradiol levels in men with schizophrenia. We have also evaluated the levels of prolactin and cortisol, taking into account the possible influence of antipsychotic drugs on both these hormones. Both prolactin and cortisol also have the potential to regulate sexual hormones biosynthesis. Our study found decreased estradiol levels in men with schizophrenia treated with clozapine and risperidone, while prolactin levels were increased only in the risperidone treated group. Cortisol levels are not statistically significant different between groups.
雌激素在精神分裂症患者中的作用是一个已受到医学界越来越多关注的课题。雌激素已被证明可抑制多巴胺的作用，促进神经元再生，并且总体上在精神分裂症的病理过程中具有保护作用。目前，针对男性的辅助雌激素疗法仍存在争议。已知抗精神病药物会通过引发不同程度的高催乳素血症来影响下丘脑 - 垂体 - 性腺轴。多项研究发现，一些非典型抗精神病药物会降低患者以及健康对照者的皮质醇水平。我们研究了氯氮平和利培酮对男性精神分裂症患者雌二醇水平的影响。我们还评估了催乳素和皮质醇的水平，同时考虑到抗精神病药物对这两种激素可能产生的影响。催乳素和皮质醇也都具有调节性激素生物合成的潜力。我们的研究发现，接受氯氮平和利培酮治疗的男性精神分裂症患者的雌二醇水平降低，而仅在接受利培酮治疗的组中催乳素水平升高。两组之间的皮质醇水平在统计学上无显著差异。
