一种便捷的四组分一锅法合成吡唑并[3,4-d]嘧啶的策略。
A convenient four-component one-pot strategy toward the synthesis of pyrazolo[3,4-d]pyrimidines.
作者信息
Liu Mingxing, Li Jiarong, Chai Hongxin, Zhang Kai, Yang Deli, Zhang Qi, Shi Daxin
机构信息
School of Chemical Engineering and Environment, Beijing Institute of Technology, Beijing, 100081, China.
出版信息
Beilstein J Org Chem. 2015 Nov 6;11:2125-31. doi: 10.3762/bjoc.11.229. eCollection 2015.
An efficient one-pot synthesis of pyrazolo[3,4-d]pyrimidine derivatives by the four-component condensation of hydrazines, methylenemalononitriles, aldehydes and alcohols has been developed via two different reaction pathways. The structures of target products were characterized by IR spectroscopy, NMR ((1)H and (13)C) spectroscopy and HRMS (ESI) spectrometry. The crystal structure of 4-ethoxy-6-(2-nitrophenyl)-1-phenyl-1H-pyrazolo[3,4-d]pyrimidine was determined by single crystal X-ray diffraction.
通过肼、亚甲基丙二腈、醛和醇的四组分缩合反应，经由两种不同的反应途径开发了一种高效的一锅法合成吡唑并[3,4-d]嘧啶衍生物的方法。目标产物的结构通过红外光谱、核磁共振（（1）H和（13）C）光谱以及高分辨质谱（电喷雾电离）进行了表征。4-乙氧基-6-（2-硝基苯基）-1-苯基-1H-吡唑并[3,4-d]嘧啶的晶体结构通过单晶X射线衍射测定。
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