Epidemiology Research Unit, Tropical Medicine Research Institute, The University of the West Indies Mona , Kingston , Jamaica.
Department of Pathology, The University of the West Indies Mona , Kingston , Jamaica.
Front Cardiovasc Med. 2014 Dec 16;1:12. doi: 10.3389/fcvm.2014.00012. eCollection 2014.
High-sensitivity C-reactive protein (hsCRP) has been shown to predict cardiovascular disease (CVD) endpoints and is associated with CVD risk factors and the metabolic syndrome. This study evaluated the association between hsCRP and CVD risk factors among Afro-Caribbean young adults in Jamaica.
We conducted a cross-sectional analysis of data from the Jamaica 1986 Birth Cohort Study. Data were collected between 2005 and 2007 when participants were 18-20 years old. All participants completed an interviewer administered questionnaire and had anthropometric and blood pressure (BP) measurements performed. Fasting blood samples were collected for measurement of glucose, lipids, and hsCRP. Logistic regression models were used to identify factors independently associated with high hsCRP.
Analyses included 342 men and 404 women with mean age 18.8 ± 0.6 years. Approximately 15% of the participants had high risk hsCRP (>3 mg/L), with a higher prevalence among women (20 vs. 9%; p < 0.001). The prevalence of elevated hsCRP increased with body mass index category, high waist circumference (WC), high triglycerides, low high density lipoprotein, and lower parental education among women, but only for high WC and lower parental education among men. In logistic regression models controlling for sex and parental education, high WC was associated with significantly higher odds of high hsCRP (OR 7.8, 95% CI 4.8-12.9, p < 0.001). In a similar model, high hsCRP was also associated with the number of metabolic syndrome components. Compared to participants with no metabolic syndrome component, having one metabolic syndrome component was associated with a twofold higher odds of high hsCRP (OR 2.2, 95% CI 1.3-3.8, p = 0.005), while having three components was associated with a 14-fold higher odds of high hsCRP (OR 13.5, 95% CI 2.4-76.0, p < 0.001).
High hsCRP is common among Jamaican young adults and is strongly associated with central obesity and the number of metabolic syndrome components.
高敏 C 反应蛋白（hsCRP）已被证明可预测心血管疾病（CVD）终点，并与 CVD 危险因素和代谢综合征相关。本研究评估了牙买加非裔加勒比年轻成年人中 hsCRP 与 CVD 危险因素之间的关系。
我们对牙买加 1986 年出生队列研究的数据进行了横断面分析。数据收集于 2005 年至 2007 年，参与者年龄在 18-20 岁之间。所有参与者完成了访谈者管理的问卷调查，并进行了人体测量和血压（BP）测量。采集空腹血样测量血糖、血脂和 hsCRP。使用逻辑回归模型确定与高 hsCRP 独立相关的因素。
分析包括 342 名男性和 404 名女性，平均年龄为 18.8±0.6 岁。约 15%的参与者 hsCRP 水平较高（>3mg/L），女性的患病率更高（20%比 9%；p<0.001）。hsCRP 升高的患病率随体重指数类别、高腰围（WC）、高甘油三酯、低高密度脂蛋白和女性受教育程度较低而增加，但仅在男性中与高 WC 和低受教育程度相关。在校正性别和父母教育程度的逻辑回归模型中，高 WC 与 hsCRP 显著升高的几率显著相关（OR7.8，95%CI4.8-12.9，p<0.001）。在类似的模型中，hsCRP 也与代谢综合征成分数量相关。与没有代谢综合征成分的参与者相比，有一个代谢综合征成分的参与者发生高 hsCRP 的几率增加两倍（OR2.2，95%CI1.3-3.8，p=0.005），而有三个成分的参与者发生高 hsCRP 的几率增加 14 倍（OR13.5，95%CI2.4-76.0，p<0.001）。
高 hsCRP 在牙买加年轻成年人中很常见，与中心性肥胖和代谢综合征成分数量密切相关。
