Biochemistry Department, Faculty of Pharmacy, Arab International University, Damascus, Syria.
Sci Rep. 2019 Oct 23;9(1):15189. doi: 10.1038/s41598-019-51658-z.
In Syria, high-Sensitive C-Reactive (hsCRP), folate, and, other health risk data in young women are limited. This cross-sectional study evaluates hsCRP and folate levels along with anthropometric characteristics, lifestyle factors and some biomarkers linked to cardiovascular disease (CVD) risk factors in healthy female students (n = 207, 18-25 years old). Among participants, hsCRP level was at average or high risk of CVD in 20.7% and 2.5% respectively and it was significantly higher in participants who had high body mass index (BMI) (Nonparametric statistical tests, p value < 0.05). Unexpectedly, it did not vary significantly between smokers and nonsmokers. And, it correlated positively with anthropometric and erythrocyte sedimentation rate (ESR) measurements. While folate level was low in 3.4% of participants, no association between hsCRP and folate levels was found. Finally, low hemoglobin level and habit of waterpipe smoking are spreading; and, sport practicing is shrinking. After reviewing similar works, this study suggests that the possible correlation between hsCRP and folate could be displayed in patients older than 30 years. Also, the marked decrease in hemoglobin level needs more attention. Finally, young females in Syria are advised to consider a lifestyle free of smoking and packed with physical activity.
在叙利亚,有关年轻女性的高敏 C 反应蛋白(hsCRP)、叶酸和其他健康风险数据十分有限。本横断面研究评估了健康女学生(n=207,年龄 18-25 岁)的 hsCRP 和叶酸水平以及与心血管疾病(CVD)风险因素相关的人体测量特征、生活方式因素和一些生物标志物。在参与者中,hsCRP 水平平均或处于 CVD 高风险的比例分别为 20.7%和 2.5%,在体重指数(BMI)较高的参与者中明显更高(非参数统计检验,p 值<0.05)。出乎意料的是,hsCRP 水平在吸烟者和不吸烟者之间没有显著差异。hsCRP 与人体测量和红细胞沉降率(ESR)测量呈正相关。虽然有 3.4%的参与者叶酸水平较低,但未发现 hsCRP 和叶酸水平之间存在关联。最后,低血红蛋白水平和水烟吸烟习惯正在蔓延,而体育锻炼的习惯正在减少。在回顾了类似的研究后,本研究表明 hsCRP 和叶酸之间可能存在关联,但这种关联可能仅在 30 岁以上的患者中表现出来。此外,血红蛋白水平的显著下降需要引起更多关注。最后,建议叙利亚的年轻女性考虑一种不吸烟且充满体育活动的生活方式。