Lai Ning-Sheng, Wang Chun-Lung, Lu Ming-Chi, Koo Malcolm
Division of Allergy, Immunology and Rheumatology, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Dalin, Chiayi, Taiwan.
School of Medicine, Tzu Chi University, Hualien, Taiwan.
Tzu Chi Med J. 2017 Jul-Sep;29(3):171-173. doi: 10.4103/tcmj.tcmj_62_17.
To evaluate the association between rheumatoid arthritis (RA) and cardiovascular comorbidities, including hyperlipidemia, hypertension, and diabetes, in Taiwanese patients based on the data from medical records.
A retrospective study was performed using the computerized medical records from a regional hospital located in southern Taiwan. A total of 2293 patients (age range 30-79 years) with a diagnosis of RA (International Classification of Diseases, Ninth Revision, Clinical Modification code 714.0) treated since the opening of the study hospital in July 2000 until February 2013 were included. The RA cases were frequency matched for age and sex with 9172 patients without RA. The associations of RA with hyperlipidemia, hypertension, and diabetes were evaluated using multiple logistic regression analysis.
Significant associations between RA and hyperlipidemia (adjusted odds ratio [OR] = 2.05, 95% confidence interval [CI] = 1.77-2.38, < 0.001) and hypertension (adjusted OR = 2.76, 95% CI = 2.43-3.14, < 0.001) were observed. However, diabetes was not significantly associated with RA in either male or female patients.
Findings from this retrospective medical record study indicated that hyperlipidemia and hypertension were significant cardiovascular comorbidities of RA.
基于病历数据评估台湾患者类风湿关节炎（RA）与心血管共病（包括高脂血症、高血压和糖尿病）之间的关联。
采用台湾南部一家地区医院的电子病历进行回顾性研究。纳入自2000年7月研究医院开业至2013年2月期间共2293例诊断为RA（国际疾病分类第九版临床修订本代码714.0）的患者（年龄范围30 - 79岁）。将RA病例按年龄和性别与9172例无RA的患者进行频数匹配。采用多因素logistic回归分析评估RA与高脂血症、高血压和糖尿病之间的关联。
观察到RA与高脂血症（调整优势比[OR]=2.05，95%置信区间[CI]=1.77 - 2.38，P<0.001）和高血压（调整OR = 2.76，95% CI = 2.43 - 3.14，P<0.001）之间存在显著关联。然而，无论是男性还是女性患者，糖尿病与RA均无显著关联。
这项回顾性病历研究结果表明，高脂血症和高血压是RA显著的心血管共病。
