Department of Cardiovascular Diseases, Internal Medicine Clinic, University Hospital Osijek, J. Huttlera 4, Osijek, 31000, Croatia.
Faculty of Medicine Osijek, Department of Internal Medicine, University J.J. Strossmayer, J. Huttlera 4, Osijek, 31000, Croatia.
BMC Cardiovasc Disord. 2024 Jun 4;24(1):291. doi: 10.1186/s12872-024-03963-3.
Patients with rheumatoid arthritis have significant cardiovascular mortality and morbidity.
To investigate the effects of chronic inflammation in rheumatoid arthritis on cardiovascular morbidity association with cardiovascular risk factors risk factors. Mortality report is secondary just to show trends without sufficient statistical power as it is accidental endpoint.
A total of 201 individuals without previous cardiovascular disease, 124 with rheumatoid arthritis (investigation group) and 77 with osteoarthritis (control group), were included in the study and followed up for an average of 8 years to assess the development of fatal or non-fatal cardiovascular diseases. The incidence and prevalence of cardiovascular risk factors were also investigated.
The total incidence of one or more fatal or nonfatal cardiovascular events was 43.9% in the investigation group and 37.5% in the control group. Of these patients, 31.7% and 30.9% survived cardiovascular events in the investigation and control groups, respectively. The most common cardiovascular disease among participants who completed the study and those who died during the study was chronic heart failure. The results of the subgroup analysis showed that strict inflammation control plays a central role in lowering cardiovascular risk.
A multidisciplinary approach to these patients is of paramount importance, especially with the cooperation of immunologists and cardiologists for early detection, prevention, and management of cardiovascular risks and diseases.
类风湿关节炎患者存在显著的心血管死亡和发病风险。
探讨类风湿关节炎慢性炎症与心血管发病风险因素的关系。死亡率报告仅作为次要终点，旨在显示趋势，但由于统计效力不足，并非真正的终点。
共纳入 201 名无既往心血管疾病的个体，其中 124 名为类风湿关节炎患者（观察组），77 名为骨关节炎患者（对照组），平均随访 8 年，评估致命或非致命心血管疾病的发生情况。还调查了心血管风险因素的发生率和流行率。
观察组总发生率为 43.9%，对照组为 37.5%。在观察组和对照组中，分别有 31.7%和 30.9%的患者存活至心血管事件。在完成研究的患者和研究期间死亡的患者中，最常见的心血管疾病是慢性心力衰竭。亚组分析结果表明，严格控制炎症对降低心血管风险起着核心作用。
对这些患者采取多学科方法至关重要，特别是免疫学家和心脏病学家的合作，以实现心血管风险和疾病的早期发现、预防和管理。
