Cannone Grazia Antonella, Lo Monaco Maria Giovanna Burgio, Carone Simona, Melcarne Anna, Tanzarella Margherita, Bisceglia Lucia, Ardizzone Antonino, Minerba Sante, Quarta Fabrizio, Coviello Vincenzo
Epidemiol Prev. 2015;39(3):176-82.
to investigate, for the first time, the incidence rates of malignant childhood cancers (children aged 0-14 years) in Apulia Region (Southern Italy) in the period 2003-2008.
to compute incidence rates of childhood cancers from Apulia Region Cancer Registry database compared with the corresponding results published in 2012 by the Italian cancer registries network (AIRTUM),where data from the Apulia population were not included, because not available.
we selected all incident cases of malignant tumours (behaviour: /3 of ICD-O-3 classification) in children aged 0-14 registered in the Apulia cancer registry. Local health unit (LHU) of Lecce (section of the Apulia cancer registry) collected data from 2003 to 2006; LHU of Taranto, BT, and Brindisi collected data from 2006 to 2008.
we computed crude, age specific, and directly standardised rates (DSR), with 95% confidence intervals, of all malignant tumours, all categories and 5 subgroups of the ICCC-3 classification; standardised incidence ratios (SIR) for all childhood malignant tumours using the rates of the AIRTUM Pool 2003-2008 as reference .
incident cases were 183. DSR (x106) of all childhood malignant tumours are: Apulia Region 169.7 (95%CI 145.9- 196.4); Brindisi 160.4 (95%CI 106.2-232.9); BT 177.7 (95%CI 122.7-248.7); Lecce 144.3 (95%CI 111.1-184.2); Taranto 216.2 (95%CI 163.0-281.4). SIR estimates are: Apulia Region 102.9 (95%CI 88.5-119.0); Brindisi 100.2 (95%CI 66.6-144.9); BT 105.4 (95%CI 73.0-147.2); Lecce 85.5 (95%CI 66.0-109.0); Taranto 134.6 (95%CI 101.7-174.8). Main incidence measures for all ICCC-3 categories and five subgroups of childhood cancers in Apulia are also reported.
in Apulia Region, we estimated a DSR for all childhood malignant tumours very close to that of the AIRTUM Pool. DSRs for each ICCC-3 category look comparable with the data from the national survey too. When data of each LHU were analysed, the SIR estimate makes it evident an excess of all malignant childhood cancers in the LHU of Taranto. Other results of particular cancers and specific age groups also provide suggestions for further investigations.
首次调查2003 - 2008年期间意大利南部普利亚大区0至14岁儿童恶性肿瘤的发病率。
根据普利亚大区癌症登记数据库计算儿童癌症发病率，并与意大利癌症登记网络（AIRTUM）2012年公布的相应结果进行比较，该网络公布的结果中未包含普利亚地区的数据，因为当时数据不可用。
我们选取了普利亚癌症登记处登记的0至14岁儿童中所有恶性肿瘤（ICD - O - 3分类中的行为：/3）的发病病例。莱切的当地卫生单位（普利亚癌症登记处的部门）收集了2003年至2006年的数据；塔兰托、BT和布林迪西的当地卫生单位收集了2006年至2008年的数据。
我们计算了所有恶性肿瘤、ICCC - 3分类的所有类别和5个亚组的粗发病率、年龄别发病率和直接标准化发病率（DSR）及其95%置信区间；以AIRTUM 2003 - 2008汇总数据的发病率为参考，计算所有儿童恶性肿瘤的标准化发病比（SIR）。
发病病例为183例。所有儿童恶性肿瘤的DSR（×10⁶）为：普利亚大区169.7（95%CI 145.9 - 196.4）；布林迪西160.4（95%CI 106.2 - 232.9）；BT 177.7（95%CI 122.7 - 248.7）；莱切144.3（95%CI 111.1 - 184.2）；塔兰托216.2（95%CI 163.0 - 281.4）。SIR估计值为：普利亚大区102.9（95%CI 88.5 - 119.0）；布林迪西100.2（95%CI 66.6 - 144.9）；BT 105.4（95%CI 73.0 - 147.2）；莱切85.5（95%CI 66.0 - 109.0）；塔兰托134.6（95%CI 101.7 - 174.8）。还报告了普利亚地区ICCC - 3所有类别和儿童癌症5个亚组的主要发病指标。
在普利亚大区，我们估计所有儿童恶性肿瘤的DSR与AIRTUM汇总数据非常接近。ICCC - 3各分类的DSR与全国调查数据也具有可比性。分析各当地卫生单位的数据时，SIR估计值表明塔兰托当地卫生单位所有儿童恶性肿瘤发病存在超额情况。特定癌症和特定年龄组的其他结果也为进一步研究提供了建议。
