来自药用植物裸茎楤木内生菌的抗分枝杆菌天然产物
Antimycobacterial Natural Products from Endophytes of the Medicinal Plant Aralia nudicaulis.
作者信息
Li Haoxin, Doucet Brandon, Flewelling Andrew J, Jean Stéphanie, Webster Duncan, Robichaud Gilles A, Johnson John A, Gray Christopher A
出版信息
Nat Prod Commun. 2015 Oct;10(10):1641-2.
Antimycobacterial extracts of a Penicillium sp. (isolate HL4-159-41B) and a Coniothyrium sp. (isolate HL6-097-027B) isolated from the rhizomes of the Canadian medicinal plant Aralia nudicaulis were found to contain palitantin (1) and botrallin (2), craterellin C (3), mycosporulone (4), spiromassaritone (5), and massarigenin D (6) respectively. Bioassays against Mycobacterium tuberculosis H37Ra revealed that 1 - 4 possess moderate antimycobacterial activity.
从加拿大药用植物短梗五加的根茎中分离出的一株青霉菌（菌株HL4-159-41B）和一株盾壳霉属真菌（菌株HL6-097-027B）的抗分枝杆菌提取物，分别被发现含有帕利坦汀（1）和波曲菌素（2）、小皮伞菌素C（3）、枝孢菌酮（4）、螺马萨里酮（5）和马萨里菌素D（6）。针对结核分枝杆菌H37Ra的生物测定表明，1-4具有中等抗分枝杆菌活性。
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