具有免疫抑制活性的食用真菌中的倍半萜类化合物
Meroterpenoids with Immunosuppressive Activity from Edible Fungus .
机构信息
School of Pharmaceutical Sciences, South-Central Minzu University, Wuhan 430074, China.
Hubei Key Laboratory of Radiation Chemistry and Functional Materials, Non-Power Nuclear Technology Collaborative Innovation Center, School of Nuclear Technology and Chemistry and Biology, Hubei University of Science and Technology, Xianning 437100, China.
出版信息
Molecules. 2023 Feb 6;28(4):1564. doi: 10.3390/molecules28041564.
Two unusual polyketide-sesquiterpene metabolites, craterodoratins T () and U (), along with the known compound craterellin A (), were isolated from the higher fungus . The structures of isolated compounds were characterized based on nuclear magnetic resonance (NMR) and mass spectrum (MS) spectroscopic analysis, while the absolute configuration of the compounds was determined by theoretical NMR and electronic circular dichroism (ECD) calculations. Compound possessed a rare structure with two aromatic groups. Compounds and showed immunosuppressive activity with IC values ranging from 5.516 to 19.953 M.
从高等真菌 中分离得到两个不寻常的聚酮-倍半萜类代谢产物 craterodoratins T()和 U()，以及已知化合物 craterellin A()。通过核磁共振（NMR）和质谱（MS）光谱分析对分离得到的化合物的结构进行了表征，而化合物的绝对构型则通过理论 NMR 和电子圆二色性（ECD）计算来确定。化合物 具有罕见的两个芳基结构。化合物 和 表现出免疫抑制活性，IC 值范围为 5.516 至 19.953 M。
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