来自内生真菌拟茎点霉属PSU-D15的代谢产物。

Metabolites from the endophytic fungus Phomopsis sp. PSU-D15.

作者信息

Rukachaisirikul Vatcharin, Sommart Ubonta, Phongpaichit Souwalak, Sakayaroj Jariya, Kirtikara Kanyawim

机构信息

Department of Chemistry, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla 90112, Thailand.

出版信息

Phytochemistry. 2008 Feb;69(3):783-7. doi: 10.1016/j.phytochem.2007.09.006. Epub 2007 Oct 22.

DOI:10.1016/j.phytochem.2007.09.006

PMID:17950385

Abstract

From the endophytic fungus Phomopsis sp. PSU-D15, three metabolites named as phomoenamide (1), phomonitroester (2) and deacetylphomoxanthone B (3), were isolated together with three known compounds, dicerandrol A (4), (1S,2S,4S)-p-menthane-1,2,4-triol (5) and uridine. Their structures were elucidated by spectroscopic methods. Phomoenamide (1) exhibited moderate in vitro antimycobacterial activity against Mycobacterium tuberculosis H37Ra.

摘要

从内生真菌拟茎点霉PSU-D15中，分离得到了三种代谢产物，分别命名为拟茎点霉酰胺（1）、拟茎点霉硝基酯（2）和去乙酰基茎点黄烷酮B（3），同时还分离得到了三种已知化合物，二色瑞香酚A（4）、(1S,2S,4S)-对薄荷烷-1,2,4-三醇（5）和尿苷。通过光谱方法对它们的结构进行了鉴定。拟茎点霉酰胺（1）对结核分枝杆菌H37Ra表现出中等程度的体外抗分枝杆菌活性。