Berrocal A, Arance A, Espinosa E, Castaño A G, Cao M G, Larriba J L G, Martín J A L, Márquez I, Soria A, Algarra S M
Servicio de Oncología Médica, Consorcio Hospital General Universitario de Valencia, Avda. Tres Cruces 2, 46014, Valencia, Spain.
Hospital Clinic I Provincial de Barcelona, Barcelona, Spain.
Clin Transl Oncol. 2015 Dec;17(12):1030-5. doi: 10.1007/s12094-015-1450-4. Epub 2015 Dec 15.
All melanoma patients must be confirmed histologically and resected according to Breslow. Sentinel node biopsy must be done when tumor is over 1 mm or if less with high-risk factors. Adjuvant therapy with interferon must be offered for patients with high-risk melanoma and in selected cases radiotherapy can be added. Metastatic melanoma treatment is guided by mutational BRAF status. BRAF wild type patients must receive anti-PD1 therapy and BRAF mutated patients BRAF/MEK inhibitors or anti-PD1 therapy. Up to 10 years follow up is recommended for melanoma patients with dermatologic examinations and physical exams.
所有黑色素瘤患者必须经组织学确诊,并根据 Breslow 方法进行切除。当肿瘤厚度超过 1 毫米或厚度较薄但具有高危因素时,必须进行前哨淋巴结活检。高危黑色素瘤患者必须接受干扰素辅助治疗,在某些情况下可加用放疗。转移性黑色素瘤的治疗以 BRAF 突变状态为指导。BRAF 野生型患者必须接受抗 PD1 治疗,BRAF 突变患者接受 BRAF/MEK 抑制剂或抗 PD1 治疗。建议对黑色素瘤患者进行长达 10 年的随访,包括皮肤科检查和体格检查。