Interdepartmental Graduate Program in Nutritional Sciences and Department of Food Science and Human Nutrition, Iowa State University , Ames, Iowa 50011, United States.
J Agric Food Chem. 2016 Jan 13;64(1):120-4. doi: 10.1021/acs.jafc.5b04347. Epub 2015 Dec 31.
Type 2 diabetes (T2D) is characterized by vitamin D deficiency owing to increased urinary loss of 25-hydroxycholecalciferol (25D). Whole eggs are a rich source of vitamin D, particularly 25D, the circulating form that reflects status. Zucker diabetic (type 2) fatty (ZDF) rats and their lean counterparts were fed casein- or whole egg-based diets for 8 weeks. Whole egg consumption attenuated both hyperglycemia and hypertriglyceridemia, as well as reduced weight gain in ZDF rats compared to casein-fed diabetic rats. Circulating 25D was lower in casein-fed ZDF rats compared to lean controls; however, ZDF rats fed whole egg exhibited the same circulating 25D concentration as casein-fed lean rats. These data suggest that dietary whole egg can attenuate metabolic anomalies, as well as maintain normal circulating 25D concentrations in T2D rats. This finding may support new dietary recommendations targeting vitamin D deficiency prevention in T2D.
2 型糖尿病（T2D）的特征是由于 25-羟胆钙化醇（25D）的尿丢失增加而导致维生素 D 缺乏。全蛋是维生素 D 的丰富来源，特别是 25D，这是反映状态的循环形式。给 Zucker 糖尿病（2 型）肥胖（ZDF）大鼠及其瘦型大鼠喂食基于酪蛋白或全蛋的饮食 8 周。与酪蛋白喂养的糖尿病大鼠相比，全蛋摄入可减轻 ZDF 大鼠的高血糖和高甘油三酯血症，并减轻体重增加。与瘦型对照组相比，酪蛋白喂养的 ZDF 大鼠的循环 25D 水平较低；然而，摄入全蛋的 ZDF 大鼠的循环 25D 浓度与酪蛋白喂养的瘦型大鼠相同。这些数据表明，饮食中的全蛋可以减轻代谢异常，并维持 T2D 大鼠的正常循环 25D 浓度。这一发现可能支持针对 T2D 维生素 D 缺乏预防的新饮食建议。
