L-3,4-二羟基苯丙氨酸诱导的超敏反应模拟去神经支配的特征。
L-3,4-dihydroxyphenylalanine-induced hypersensitivity simulating features of denervation.
作者信息
Tang L C, Cotzias G C
出版信息
Proc Natl Acad Sci U S A. 1977 May;74(5):2126-9. doi: 10.1073/pnas.74.5.2126.
Abstract
The manner in which dyskinesia and intermittency of neurological control had emerged late in the therapy of Parkinsonism with L-3,4-dihydroxyphenylalanine (levodopa) had suggested to us that this drug can imprint on the brain a chemical memory of its passage. The majority of authors ascribed these events to denervation hypersensitivity caused by the nigral and other lesions of the disease. By feeding levodopa to mice, however, we induced a state that simulated denervations hypersensitivity, including hyperreaction to single injections of levodopa and increased dopamine-stimulated adenylate cyclase [ATP pyrophosphate-lyase (cyclizing), EC 4.6.1.1] activity in homogenates of caudate nuclei. These phenomena were not caused by actual denervation, because the hypersensitivity declined and disappeared some weeks after the dietary levodopa was stopped.
摘要
在使用L-3,4-二羟基苯丙氨酸（左旋多巴）治疗帕金森病的后期出现运动障碍和神经控制间歇性的方式，向我们表明这种药物可以在大脑中留下其通过的化学记忆。大多数作者将这些事件归因于该疾病黑质及其他病变引起的去神经超敏反应。然而，通过给小鼠喂食左旋多巴，我们诱导出一种模拟去神经超敏反应的状态，包括对单次注射左旋多巴的过度反应以及尾状核匀浆中多巴胺刺激的腺苷酸环化酶[ATP焦磷酸裂解酶（环化），EC 4.6.1.1]活性增加。这些现象并非由实际的去神经支配引起，因为在停止喂食左旋多巴几周后，超敏反应会减弱并消失。
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本文引用的文献
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Quantitative recording of rotational behavior in rats after 6-hydroxy-dopamine lesions of the nigrostriatal dopamine system.黑质纹状体多巴胺系统6-羟基多巴胺损伤后大鼠旋转行为的定量记录。
Brain Res. 1970 Dec 18;24(3):485-93. doi: 10.1016/0006-8993(70)90187-3.
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Dopamine in the mesolimbic system of the rat brain: endogenous levels and the effects of drugs on the uptake mechanism and stimulation of adenylate cyclase activity.大鼠脑边缘系统中的多巴胺：内源性水平以及药物对摄取机制和腺苷酸环化酶活性刺激的影响。
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Levodopa, manganese, and degenerations of the brain.左旋多巴、锰与脑变性
Harvey Lect. 1974;68:115-47.
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