Neville R F, Bartorelli A L, Sidawy A N, Almagor Y, Potkin B, Leon M B
National Institutes of Health, Bethesda, Maryland 20892.
Am J Surg. 1989 Aug;158(2):142-5. doi: 10.1016/0002-9610(89)90363-2.
Increasingly complex vascular reconstructions and emerging endovascular therapeutic modalities have stimulated the need for improved vascular imaging. To determine the feasibility of in vivo intravascular ultrasound, a miniature probe 1 mm in diameter with a 25 MHz center frequency was used to obtain two-dimensional, 360-degree cross-sectional images. In sheep, 14 superficial femoral arteries were imaged at different sites, and a portion of each vessel was resected for immediate in vitro imaging and histologic examination. In vivo images clearly showed the intima, media, and adventitia of the vessel wall as well as the lumen-intima and media-adventitia interfaces. There was a significant correlation in measured lumen area between resected artery ultrasound images and histologic sections. We conclude that intravascular ultrasound can produce high-resolution dynamic images that demonstrate vessel wall architecture and allow precise calculation of lumen area.
日益复杂的血管重建术和新兴的血管内治疗方式激发了对改进血管成像的需求。为了确定体内血管内超声检查的可行性，使用了一个直径为1毫米、中心频率为25兆赫的微型探头来获取二维360度横截面图像。在绵羊身上，对14条股浅动脉的不同部位进行成像，并切除每条血管的一部分以便立即进行体外成像和组织学检查。体内图像清晰地显示了血管壁的内膜、中膜和外膜以及管腔-内膜和中膜-外膜界面。切除动脉的超声图像与组织学切片之间测得的管腔面积存在显著相关性。我们得出结论，血管内超声可以产生高分辨率动态图像，显示血管壁结构并允许精确计算管腔面积。
