Bartorelli A L, Neville R F, Keren G, Almagor Y, Potkin B N, Gessert J M, Leon M B
Cardiology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892.
Am J Card Imaging. 1991 Mar;5(1):60-4.
Recent in vitro studies have demonstrated that intravascular ultrasound can obtain high-resolution cross-sectional images of arterial vessels. To further expand the use of this technique for in vivo visualization of peripheral and coronary vessels, we imaged 24 femoral and 13 carotid arteries from 19 sheep. Using a manual rotation technique, high-resolution images were obtained in 95% of the vessel sites with a rigid probe and in 82% of the vessel sites with a flexible catheter. In 14 of these arteries, good correlation was found between the lumen diameter measured by ultrasound and by angiography (P less than .001, r = .91). In addition, 6 left circumflex coronary arteries were imaged from 6 additional sheep by motor-driven rotation of the ultrasound probe at 1,800 rotations per minute, obtaining clear delineation of coronary lumen morphology and lumen-intima interface. Strong correlation was found also between intravascular ultrasound and cineangiography for coronary artery diameter measurement (P less than .001, r = .96). These studies demonstrate that this technique can provide high-resolution images of arterial vessels in vivo and may have unique advantages in diagnosis of atherosclerotic vascular disease and in the guidance of new catheter-based therapeutic modalities.
最近的体外研究表明，血管内超声能够获取动脉血管的高分辨率横截面图像。为了进一步扩大这项技术在体内可视化外周血管和冠状动脉方面的应用，我们对19只绵羊的24条股动脉和13条颈动脉进行了成像。使用手动旋转技术，使用刚性探头在95%的血管部位获得了高分辨率图像，使用柔性导管在82%的血管部位获得了高分辨率图像。在其中14条动脉中，发现超声测量的管腔直径与血管造影测量的管腔直径之间具有良好的相关性（P小于0.001，r = 0.91）。此外，通过以每分钟1800转的速度对超声探头进行电动旋转，对另外6只绵羊的6条左旋冠状动脉进行了成像，清晰地描绘了冠状动脉管腔形态和管腔 - 内膜界面。在冠状动脉直径测量方面，血管内超声与电影血管造影之间也发现了很强的相关性（P小于0.001，r = 0.96）。这些研究表明，这项技术能够在体内提供动脉血管的高分辨率图像，并且在动脉粥样硬化性血管疾病的诊断以及基于导管的新治疗方式的引导方面可能具有独特的优势。
