Wenguang L, Gussenhoven W J, Zhong Y, The S H, Di Mario C, Madretsma S, van Egmond F, de Feyter P, Pieterman H, van Urk H
Thoraxcenter, Department of Radiology, University Hospital Rotterdam-Dijkzigt, Erasmus University, The Netherlands.
Int J Card Imaging. 1991;6(3-4):247-53. doi: 10.1007/BF01797856.
This study investigated the accuracy and reproducibility of a computer-aided method for quantification of intravascular ultrasound. The computer analysis system was developed on an IBM compatible PC/AT equipped with a framegrabber. The quantitative assessment of lumen area, lesion area and percent area obstruction was performed by tracing the boundaries of the free lumen and original lumen. Accuracy of the analysis system was tested in a phantom study. Echographic measurements of lumen and lesion area derived from 16 arterial specimens were compared with data obtained by histology. The differences in lesion area measurements between histology and ultrasound were minimal (mean +/- SD: -0.27 +/- 1.79 mm2, p greater than 0.05). Lumen area measurements from histology were significantly smaller than those with ultrasound due to mechanical deformation of histologic specimens (-5.38 +/- 5.09 mm2, p less than 0.05). For comparison with angiography, 18 ultrasound cross-sections were obtained in vivo from 8 healthy peripheral arteries. Luminal areas obtained by angiography were similar to those by ultrasound (-0.52 +/- 5.15 mm2, p greater than 0.05). Finally, intra- and interobserver variability of our quantitative method was evaluated in measurements of 100 in vivo ultrasound images. The results showed that variations in lumen area measurements were low (5%) whereas variations in lesion area and percent area obstruction were relatively high (13%, 10%, respectively). Results of this study indicate that our quantitative method provides accurate and reproducible measurements of lumen and lesion area. Thus, intravascular ultrasound can be used for clinical investigation, including assessment of vascular stenosis and evaluation of therapeutic intervention.
本研究调查了一种用于血管内超声定量分析的计算机辅助方法的准确性和可重复性。该计算机分析系统是在配备图像采集卡的IBM兼容PC/AT机上开发的。通过描绘自由管腔和原始管腔的边界来进行管腔面积、病变面积和面积阻塞百分比的定量评估。在模型研究中测试了分析系统的准确性。将16个动脉标本的管腔和病变面积的超声测量结果与组织学获得的数据进行比较。组织学和超声测量的病变面积差异最小（平均值±标准差：-0.27±1.79mm²，p＞0.05）。由于组织学标本的机械变形，组织学测量的管腔面积明显小于超声测量的管腔面积（-5.38±5.09mm²，p＜0.05）。为了与血管造影术进行比较，从8条健康的外周动脉体内获取了18个超声横截面。血管造影术获得的管腔面积与超声获得的管腔面积相似（-0.52±5.15mm²，p＞0.05）。最后，在对100幅体内超声图像的测量中评估了我们定量方法的观察者内和观察者间变异性。结果表明，管腔面积测量的变异性较低（5%），而病变面积和面积阻塞百分比的变异性相对较高（分别为13%、10%）。本研究结果表明，我们的定量方法能够准确且可重复地测量管腔和病变面积。因此，血管内超声可用于临床研究，包括血管狭窄的评估和治疗干预的评价。
