Marcelli-Barge A
Labortoire d'Immunologie et d'Histocompatibilité, Hôpital Saint-Louis, Paris.
Rev Fr Transfus Hemobiol. 1989 Apr;32(2):115-34. doi: 10.1016/s1140-4639(89)80031-0.
Certain types of cytopenia are due to the destruction of blood cells by an antibody, active only in conjunction with a drug which has previously provoked sensitivity in patients when administered in standard doses. Drug-induced thrombocytopenia and leucopenia of allergic origin are relatively rare. They produce characteristic symptoms, i.e. brutal onset and acute development of the disease; healing takes place when the drug in question is withdrawn. Haematological diseases of drug-related aetiology are being brought to light by serological methods which detect the specific antibody for the drug responsible for the accident. The physiopathological mechanism is still not clearly elucidated.
某些类型的血细胞减少症是由于抗体对血细胞的破坏所致，该抗体仅在与一种药物联合使用时才具有活性，这种药物在以标准剂量给药时曾引发患者的敏感性。药物诱导的过敏性血小板减少症和白细胞减少症相对罕见。它们会产生特征性症状，即疾病起病突然且发展迅速；停用相关药物后病情会痊愈。通过血清学方法可发现与药物相关病因的血液学疾病，这些方法能检测出导致该不良反应的药物的特异性抗体。其生理病理机制仍未完全阐明。
