滤过性青光眼手术后的结膜纤维化

Conjunctival fibrosis following filtering glaucoma surgery.

作者信息

Schlunck Günther, Meyer-ter-Vehn Tobias, Klink Thomas, Grehn Franz

机构信息

Eye Center, Freiburg University Medical Center, Freiburg, Germany.

Dept. of Ophthalmology, Würzburg University Hospital, Würzburg, Germany.

出版信息

Exp Eye Res. 2016 Jan;142:76-82. doi: 10.1016/j.exer.2015.03.021.

DOI:10.1016/j.exer.2015.03.021

PMID:26675404

Abstract

Despite advances in surgical technique and postoperative care, fibrosis remains the major impediment to a marked reduction of intraocular pressure without the need of additional medication (complete success) following filtering glaucoma surgery. Several aspects specific to filtering surgery may contribute to enhanced fibrosis. Changes in conjunctival tissue structure and composition due to preceding treatments as well as alterations in interstitial fluid flow and content due to aqueous humor efflux may act as important drivers of fibrosis. In light of these pathophysiological considerations, current and possible future strategies to control fibrosis following filtering glaucoma surgery are discussed.

摘要

尽管手术技术和术后护理取得了进展，但纤维化仍然是滤过性青光眼手术后无需额外药物就能显著降低眼压（完全成功）的主要障碍。滤过性手术的几个特定方面可能会导致纤维化加剧。先前治疗引起的结膜组织结构和成分变化，以及房水流出导致的间质液流动和含量改变，可能是纤维化的重要驱动因素。鉴于这些病理生理因素，本文讨论了当前以及未来可能用于控制滤过性青光眼手术后纤维化的策略。