来自大葱的两种新型双环亚砜。

Two new bicyclic sulfoxides from Welsh onion.

作者信息

Nohara Toshihiro, Fujiwara Yukio, Ikeda Tsuyoshi, Murakami Kotaro, Ono Masateru, El-Aasr Mona, Nakano Daisuke, Kinjo Junei

机构信息

Faculty of Pharmaceutical Sciences, Sojo University, 22-1, 4-Chome, Nishi-ku, Ikeda, Kumamoto, 860-0082, Japan.

Graduate School of Medical Sciences, Faculty of Life Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, 860-8556, Japan.

出版信息

J Nat Med. 2016 Apr;70(2):260-5. doi: 10.1007/s11418-015-0947-z. Epub 2015 Dec 16.

DOI:10.1007/s11418-015-0947-z

PMID:26676612

Abstract

Newly identified bicyclic sulfoxides, welsonins A1 (1) and A2 (2), were isolated from acetone extracts of the bulbs of the Welsh onion (Allium fistulosum). In this study, the structures of 1 and 2, which are tetrahydrothiophene-S-oxide derivatives, were characterized by spectroscopic analysis. These compounds appeared to be derived from the coupling of 1-propenyl sulfenic acid and uronic acid. Welsonin A1 (1) showed the potential to suppress tumor-cell proliferation by inhibiting the polarization of alternatively activated M2 macrophages.

摘要

从大葱（葱属）鳞茎的丙酮提取物中分离出了新鉴定的双环亚砜化合物威尔索菌素A1（1）和A2（2）。在本研究中，通过光谱分析对作为四氢噻吩 - S - 氧化物衍生物的1和2的结构进行了表征。这些化合物似乎源自1 - 丙烯基亚磺酸和糖醛酸的偶联。威尔索菌素A1（1）显示出通过抑制交替活化的M2巨噬细胞的极化来抑制肿瘤细胞增殖的潜力。