Patankar Sangeeta, Venkatraman Poornima, Sridharan Gokul, Kane Shubhada
Sangeeta Patankar, Poornima Venkatraman, Gokul Sridharan, Department of Oral Pathology and Microbiology, YMT Dental College and Hospital, Mumbai 410210, Maharashtra, India.
World J Clin Cases. 2015 Dec 16;3(12):1011-6. doi: 10.12998/wjcc.v3.i12.1011.
Burkitt's lymphoma (BL) is an aggressive form of non-Hodgkin's B-cell lymphoma with three variants namely endemic, sporadic, and immunodeficiency-associated types. It is endemic in Africa and sporadic in other parts of the world. While the endemic form is widely reported to occur in early childhood and commonly involves the jaw bones, the sporadic form typically presents as an abdominal mass. This presentation reports a rare case of sporadic form of BL clinically manifesting as a generalized gingival enlargement in an immunocompetent adult male which demonstrated an aggressive behavior. The patient reported with a prominent anterior gingival swelling of 6 mo duration which slowly enlarged in size and associated with multiple lymph node involvement. Microscopic examination of the lesion using H, E and immunohistochemical diagnosis confirmed the diagnosis as BL. The patient succumbed to the disease before any therapy could be instituted. Since a wide array of causes can be attributed to gingival enlargements, it is necessary to consider malignancies as one of the important differential diagnosis so as to facilitate the need for appropriate diagnosis and prompt treatment.
伯基特淋巴瘤(BL)是一种侵袭性非霍奇金B细胞淋巴瘤,有三种变体,即地方性、散发性和免疫缺陷相关型。它在非洲为地方性发病,在世界其他地区为散发性。虽然普遍报道地方性形式在幼儿期发病,通常累及颌骨,但散发性形式通常表现为腹部肿块。本病例报告了一例罕见的散发性BL,临床表现为免疫功能正常的成年男性广泛性牙龈肿大,呈现侵袭性。患者就诊时前牙龈明显肿胀已持续6个月,且逐渐增大,并伴有多处淋巴结受累。使用苏木精-伊红染色(H、E)和免疫组化诊断对病变进行显微镜检查,确诊为BL。患者在能够进行任何治疗之前就死于该病。由于牙龈肿大的原因多种多样,有必要将恶性肿瘤作为重要的鉴别诊断之一,以便于进行适当的诊断和及时治疗。