Kato Ronald, Solomon Kibudde
Department of Emergency Medicine Savannah Hospital Nairobi Kenya.
Division of Radiation Oncology Uganda Cancer Institute Kampala Uganda.
Clin Case Rep. 2023 Oct 17;11(10):e8081. doi: 10.1002/ccr3.8081. eCollection 2023 Oct.
Burkitt's lymphoma is a highly aggressive non-Hodgkin's lymphoma that can affect various parts of the body, which include jaw, facial bones, retroperitoneum, and abdominal viscera, it is worth noting that breast involvement is extremely rare in Burkitt's lymphoma and has not been documented.
Burkitt's lymphoma is a highly aggressive non-Hodgkin's lymphoma that can affect various parts of the body including breast. This sarcoma is identified as a rapidly fatal malignant lymphoma syndrome and 50% of all malignant tumors in children. However, breast involvement has not been documented. A 19-year-old male presented to our emergency department with a left breast swelling for 2 months associated with drenching night sweats, weight loss and evening fevers. Physical examination revealed a mass measuring approximately 15 × 16 × 15 cm in the widest dimension, skin hyperpigmentation, no nipple discolorations, discharges, and non-tender on palpation. Biopsy was done, and the histology report revealed sheets of monomorphic medium lymphocytes with a high mitotic rate and frequent apoptotic bodies showing a starry-sky appearance. The immunohistochemistry report revealed positive staining for Ki-67, CD-20, and CD-10 tumor markers and CD45 on flow cytometry. The patient was started on aggressive hydration, rasubricase administration, CODOX-M/IVAC regimen 6 cycles, and G-CSF and registered significant reduction in the size of the mass. Burkitt's lymphoma is a highly aggressive non-Hodgkin's lymphoma that can affect various parts of the body. It commonly involves the jaw, facial bones, retroperitoneum, and abdominal viscera. The disease typically affects young patients in areas of high incidence, such as the jaw, whereas visceral involvement is more common in older patients in low-incidence areas. It is worth noting that breast involvement is extremely rare in Burkitt's lymphoma.
伯基特淋巴瘤是一种侵袭性很强的非霍奇金淋巴瘤，可累及身体各个部位，包括颌骨、面骨、腹膜后和腹部脏器，值得注意的是，伯基特淋巴瘤累及乳腺极为罕见，尚无相关文献记载。
伯基特淋巴瘤是一种侵袭性很强的非霍奇金淋巴瘤，可累及包括乳腺在内的身体各个部位。这种肉瘤被认为是一种迅速致命的恶性淋巴瘤综合征，占儿童所有恶性肿瘤的50%。然而，尚无乳腺受累的文献记载。一名19岁男性因左乳肿胀2个月伴盗汗、体重减轻和低热就诊于我院急诊科。体格检查发现一个最大径约15×16×15cm的肿块，皮肤色素沉着，乳头无变色、溢液，触诊无压痛。进行了活检，组织学报告显示为成片的单形性中等淋巴细胞，有高有丝分裂率和频繁的凋亡小体，呈星空样外观。免疫组化报告显示Ki-67、CD-20和CD-10肿瘤标志物呈阳性染色，流式细胞术显示CD45阳性。患者开始积极补液、使用拉布立酶、接受6个周期的CODOX-M/IVAC方案治疗以及使用粒细胞集落刺激因子，肿块大小明显缩小。伯基特淋巴瘤是一种侵袭性很强的非霍奇金淋巴瘤，可累及身体各个部位。它通常累及颌骨、面骨、腹膜后和腹部脏器。该疾病通常在发病率高的地区影响年轻患者，如颌骨，而在内脏受累方面，在发病率低的地区老年患者中更为常见。值得注意的是，伯基特淋巴瘤累及乳腺极为罕见。
