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用于诊断口腔淋巴瘤的循证免疫组织化学检测组合及病例系列

An evidence based immunohistochemical panel for diagnosing oral lymphoma along with a case series.

作者信息

Aneesh V M, Carvalho Karla M, Dhupar Anita, Spadigam Anita

机构信息

Department of Oral and Maxillofacial Pathology, Goa Dental College and Hospital, Bambolim, Goa, India.

出版信息

J Family Med Prim Care. 2024 May;13(5):2143-2148. doi: 10.4103/jfmpc.jfmpc_1570_23. Epub 2024 May 24.

DOI:10.4103/jfmpc.jfmpc_1570_23
PMID:38948544
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11213410/
Abstract

Oral lymphomas are rare and present a diagnostic challenge. Immunophenotyping is essential to decipher their biology and identify therapeutic targets. Histopathology can prove to be diagnostically difficult to type these lesions, and hence, immunohistochemistry (IHC) proves useful in deciphering their biology. Here, we present an evidence-based approach using a novel immunohistochemical marker panel to diagnose oral lymphomas by discussing four unique cases.

摘要

口腔淋巴瘤较为罕见，诊断颇具挑战性。免疫表型分析对于解读其生物学特性及确定治疗靶点至关重要。组织病理学在对这些病变进行分型时可能存在诊断困难，因此，免疫组织化学（IHC）在解读其生物学特性方面很有用。在此，我们通过讨论四个独特病例，介绍一种基于证据的方法，即使用新型免疫组织化学标志物组合来诊断口腔淋巴瘤。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6dd0/11213410/cfdad08a4dd3/JFMPC-13-2143-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6dd0/11213410/776f01f6fc06/JFMPC-13-2143-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6dd0/11213410/cfdad08a4dd3/JFMPC-13-2143-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6dd0/11213410/776f01f6fc06/JFMPC-13-2143-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6dd0/11213410/cfdad08a4dd3/JFMPC-13-2143-g002.jpg

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本文引用的文献

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Front Immunol. 2023 Jan 26;14:1068662. doi: 10.3389/fimmu.2023.1068662. eCollection 2023.
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Lymphomas Affecting the Sublingual Glands: A Clinicopathological Study.累及舌下腺的淋巴瘤：一项临床病理研究。
Head Neck Pathol. 2023 Mar;17(1):154-164. doi: 10.1007/s12105-022-01489-8. Epub 2022 Sep 27.
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Basic immunohistochemistry for lymphoma diagnosis.用于淋巴瘤诊断的基础免疫组织化学
Blood Res. 2022 Apr 30;57(S1):55-61. doi: 10.5045/br.2022.2022037.
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An unusual case of paediatric plasmablastic lymphoma presenting with malignant effusion and the challenges in its diagnosis.儿童浆母细胞淋巴瘤伴恶性浆膜腔积液一例并诊断难点分析。
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J Stomatol Oral Maxillofac Surg. 2020 Dec;121(6):743-745. doi: 10.1016/j.jormas.2020.04.007. Epub 2020 Apr 30.
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