Goldstein B D, Czerniecki B, Witz G
Department of Environmental and Community Medicine, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway 08854-5635.
Environ Health Perspect. 1989 May;81:55-7. doi: 10.1289/ehp.898155.
A role has been suggested for free radicals and active states of oxygen in tumor promotion. There are a number of lines of support for this hypothesis, but no definitive evidence. The hypothesis has proven of value in leading to the development of models pertinent to understanding the mechanism of action of tumor promoters.
自由基和活性氧状态在肿瘤促进过程中的作用已被提出。有许多支持这一假说的线索,但尚无确凿证据。这一假说已被证明在推动与理解肿瘤促进剂作用机制相关的模型发展方面具有价值。