整合素介导的单细胞水平黏附的快速可逆光开关转换
Rapid Reversible Photoswitching of Integrin-Mediated Adhesion at the Single-Cell Level.
作者信息
Kadem Laith F, Holz Michelle, Suana Kristine Grace, Li Qian, Lamprecht Constanze, Herges Rainer, Selhuber-Unkel Christine
机构信息
Institute for Materials Science, University of Kiel, Kaiserstr. 2, 24143, Kiel, Germany.
Otto-Diels-Institute of Organic Chemistry, University of Kiel, Otto-Hahn-Platz 4, 24098, Kiel, Germany.
出版信息
Adv Mater. 2016 Mar 2;28(9):1799-802. doi: 10.1002/adma.201504394. Epub 2015 Dec 21.
Rapid and reversible photoswitching of cell adhesion is achieved by c(RGDfK)-azobenzenes embedded in a poly(ethylene glycol) background on surfaces. The light-induced cis-trans-isomerization of the azobenzene enables switching of cell adhesion on the surface. Reversibility of switching over several consecutive switching cycles is demonstrated by single-cell force spectroscopy.
通过嵌入在表面聚乙二醇背景中的c(RGDfK)-偶氮苯实现了细胞黏附的快速且可逆的光开关。偶氮苯的光诱导顺反异构化能够实现表面细胞黏附的开关切换。单细胞力谱证明了在几个连续的切换循环中切换的可逆性。
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