Fürst P, Albers S, Stehle P
Institute for Biological Chemistry and Nutrition, University of Hohenheim, FRG.
Metabolism. 1989 Aug;38(8 Suppl 1):67-72. doi: 10.1016/0026-0495(89)90145-5.
In this review, new knowledge about the potential use of glutamine containing dipeptides as substrates in the frame of parenteral nutrition is presented. Using chemical and biotechnological methods, the stable and highly soluble peptide L-alanyl-L-glutamine (Ala-Gln) can be synthesized in high yields. Studies in experimental rats and dogs demonstrate the effective utilization of intravenously supplied Ala-Gln and the rapid provision of free glutamine for maintenance of the intracellular muscle-free glutamine pool in catabolic situations. Subsequent studies in healthy volunteers provide firm evidence that the infused Ala-Gln is rapidly eliminated from plasma (t1/2:3.8 minutes), associated by a prompt equimolar increase in the concentrations of free alanine and glutamine. Bolus injection and continuous infusion of the peptide was not accompanied by any side effects, and no complaints by the subjects were noted. These results may indicate a safe and efficient use of Ala-Gln as source of free glutamine in parenteral nutrition.
在本综述中，介绍了关于含谷氨酰胺二肽作为肠外营养底物潜在用途的新知识。利用化学和生物技术方法，可以高产率合成稳定且高度可溶的肽L-丙氨酰-L-谷氨酰胺（Ala-Gln）。对实验大鼠和犬的研究表明，静脉输注的Ala-Gln能有效利用，并能迅速提供游离谷氨酰胺，以维持分解代谢状态下细胞内无肌谷氨酰胺池。随后对健康志愿者的研究提供了确凿证据，即输注的Ala-Gln能迅速从血浆中消除（半衰期：3.8分钟），同时游离丙氨酸和谷氨酰胺浓度迅速等摩尔增加。推注和持续输注该肽均未伴随任何副作用，且未观察到受试者有任何不适。这些结果可能表明Ala-Gln作为肠外营养中游离谷氨酰胺来源的使用是安全有效的。
