Cancer Center and Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, Macau SAR, 999078, China.
Institute of Medical Technology, Shanxi Medical University, Taiyuan, 030001, China.
Adv Sci (Weinh). 2023 Sep;10(27):e2302044. doi: 10.1002/advs.202302044. Epub 2023 Aug 2.
Nanofibers are long, wire-like materials with nanoscale diameters and specific length diameter ratios. Nanofibers have porous reticular networks with remarkably high specific surface areas and significant interconnectivity between pores, allowing for the chemical modification and loading of drugs. Metallized nanofibers are novel materials that enhance the performance of attributes of conventional nanofibers by combining metals with nanofibers through electrostatic spinning doping, chemical modification, and loading approaches. Due to their unique physical and chemical properties, metallized nanofibers are diverse, rapidly developed materials in the fields of physical chemistry, materials science, and battery preparation. To date, with improvement in advanced preparation techniques and biocompatibility levels for materials, metallized nanofiber applications are gradually expanding into the biomedical field due to their excellent thermal and electrical conductivities and unique metal properties. In this review, the applications of metallized nanofibers in biomedicine are summarized. It is suggested to prepare metallized multifunctional nanofibers for tissue engineering, drug delivery, tumor treatment, wound healing, and biosensing applications by taking safety and stability as the main material selection guidelines. Finally, the development of nanofibers for biomedical applications is summarized and discussed.
纳米纤维是具有纳米级直径和特定长径比的长丝状材料。纳米纤维具有多孔网状结构，具有极高的比表面积和孔之间的显著连通性，允许对药物进行化学修饰和负载。金属化纳米纤维是一种新型材料，通过静电纺丝掺杂、化学修饰和负载方法将金属与纳米纤维结合，增强了常规纳米纤维的性能属性。由于其独特的物理和化学性质，金属化纳米纤维在物理化学、材料科学和电池制备等领域是多样化且快速发展的材料。迄今为止，随着先进制备技术和材料生物相容性的提高，由于其优异的热导率和电导率以及独特的金属性质，金属化纳米纤维的应用逐渐扩展到生物医学领域。本文综述了金属化纳米纤维在生物医学中的应用。建议以安全性和稳定性为主要材料选择原则，制备用于组织工程、药物输送、肿瘤治疗、伤口愈合和生物传感应用的金属化多功能纳米纤维。最后，总结和讨论了用于生物医学应用的纳米纤维的发展。
