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患有网络游戏障碍的青少年的脑连接性与精神共病

Brain connectivity and psychiatric comorbidity in adolescents with Internet gaming disorder.

作者信息

Han Doug Hyun, Kim Sun Mi, Bae Sujin, Renshaw Perry F, Anderson Jeffrey S

机构信息

Department of Psychiatry, Chung-Ang University Hospital, Seoul, South Korea.

Industry Academic Cooperation Foundation, Chung-Ang University, Seoul, South Korea.

出版信息

Addict Biol. 2017 May;22(3):802-812. doi: 10.1111/adb.12347. Epub 2015 Dec 22.

Abstract

Prolonged Internet video game play may have multiple and complex effects on human cognition and brain development in both negative and positive ways. There is not currently a consensus on the principle effects of video game play neither on brain development nor on the relationship to psychiatric comorbidity. In this study, 78 adolescents with Internet gaming disorder (IGD) and 73 comparison subjects without IGD, including subgroups with no other psychiatric comorbid disease, with major depressive disorder and with attention deficit hyperactivity disorder (ADHD), were included in a 3 T resting state functional magnetic resonance imaging analysis. The severity of Internet gaming disorder, depression, anxiety and ADHD symptoms were assessed with the Young Internet Addiction Scale, the Beck Depression Inventory, the Beck Anxiety Inventory and the Korean ADHD rating scales, respectively. Patients with IGD showed an increased functional correlation between seven pairs of regions, all satisfying q < 0.05 False discovery rates in light of multiple statistical tests: left frontal eye field to dorsal anterior cingulate, left frontal eye field to right anterior insula, left dorsolateral prefrontal cortex (DLPFC) to left temporoparietal junction (TPJ), right DLPFC to right TPJ, right auditory cortex to right motor cortex, right auditory cortex to supplementary motor area and right auditory cortex to dorsal anterior cingulate. These findings may represent a training effect of extended game play and suggest a risk or predisposition in game players for over-connectivity of the default mode and executive control networks that may relate to psychiatric comorbidity.

摘要

长时间玩网络游戏可能会以消极和积极的方式对人类认知和大脑发育产生多种复杂影响。目前,对于玩网络游戏对大脑发育的主要影响以及与精神疾病共病的关系,尚未达成共识。在本研究中,78名患有网络游戏障碍(IGD)的青少年和73名无IGD的对照受试者被纳入3T静息态功能磁共振成像分析,其中对照受试者包括无其他精神疾病共病、患有重度抑郁症和注意力缺陷多动障碍(ADHD)的亚组。分别使用青少年网瘾量表、贝克抑郁量表、贝克焦虑量表和韩国ADHD评定量表评估网络游戏障碍、抑郁、焦虑和ADHD症状的严重程度。IGD患者在七对脑区之间表现出功能相关性增加,根据多重统计检验,所有这些脑区对均满足错误发现率q<0.05:左侧额眼区与背侧前扣带回、左侧额眼区与右侧前脑岛、左侧背外侧前额叶皮质(DLPFC)与左侧颞顶叶交界处(TPJ)、右侧DLPFC与右侧TPJ、右侧听觉皮层与右侧运动皮层、右侧听觉皮层与辅助运动区以及右侧听觉皮层与背侧前扣带回。这些发现可能代表了长时间游戏的训练效果,并提示游戏玩家存在默认模式和执行控制网络过度连接的风险或易感性,这可能与精神疾病共病有关。

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