Zhang Yanzhen, Mei Wei, Zhang John X, Wu Qiulin, Zhang Wei
School of Psychology and Center for Studies of Psychological Application, South China Normal University, Guangzhou, 510631, China.
Higher Medical Education Center, Medical College of Shantou University, Shantou, 515041, China.
Exp Brain Res. 2016 Sep;234(9):2553-60. doi: 10.1007/s00221-016-4659-8. Epub 2016 Apr 27.
The insula is a region that integrates interoception and drug urges, but little is known about its role in behavioral addiction such as internet addiction. We investigated insula-based functional connectivity in participants with internet gaming disorder (IGD) and healthy controls (HC) using resting-state functional MRI. The right and left insula subregions (posterior, ventroanterior, and dorsoanterior) were used as seed regions in a connectivity analysis. Compared with the HC group, the IGD group showed decreased functional connectivity between left posterior insula and bilateral supplementary motor area and middle cingulated cortex, between right posterior insula and right superior frontal gyrus, and decreased functional integration between insular subregions. The finding of reduced functional connectivity between the interoception and the motor/executive control regions is interpreted to reflect reduced ability to inhibit motor responses to internet gaming or diminished executive control over craving for internet gaming in IGD. The results support the hypothesis that IGD is associated with altered insula-based network, similar to substance addiction such as smoking.
脑岛是一个整合内感受和药物冲动的区域，但对于其在诸如网络成瘾等行为成瘾中的作用却知之甚少。我们使用静息态功能磁共振成像技术，对患有网络游戏障碍（IGD）的参与者和健康对照组（HC）基于脑岛的功能连接性进行了研究。在连接性分析中，将左右脑岛亚区（后部、腹侧前部和背侧前部）用作种子区域。与HC组相比，IGD组在左后脑岛与双侧辅助运动区及中央扣带回之间、右后脑岛与右上额叶回之间的功能连接性降低，且脑岛亚区之间的功能整合也降低。内感受与运动/执行控制区域之间功能连接性降低这一发现被解释为反映了IGD患者抑制对网络游戏的运动反应的能力下降，或对网络游戏渴望的执行控制减弱。结果支持了这样一种假设，即IGD与基于脑岛的网络改变有关，类似于吸烟等物质成瘾。
