Panda Santanu, Coffin Aaron, Nguyen Q Nhu, Tantillo Dean J, Ready Joseph M
Department of Biochemistry, Division of Chemistry, UT Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX, 75390-0938, USA.
Department of Chemistry, UC Davis, One Shields Ave, Davis, CA, 95616, USA.
Angew Chem Int Ed Engl. 2016 Feb 5;55(6):2205-9. doi: 10.1002/anie.201510027. Epub 2015 Dec 22.
When activated by an acylating agent, pyridine boronic esters react with organometallic reagents to form a dihydropyridine boronic ester. This intermediate allows access to a number of valuable substituted pyridine, dihydropyridine, and piperidine products.
当被酰化剂激活时,吡啶硼酸酯与有机金属试剂反应形成二氢吡啶硼酸酯。这种中间体可用于制备多种有价值的取代吡啶、二氢吡啶和哌啶产物。