手性 α-氨基叔硼酸酯的对映选择性硼氢化合成 α-芳烯酰胺。
Synthesis of Chiral α-Amino Tertiary Boronic Esters by Enantioselective Hydroboration of α-Arylenamides.
机构信息
State Key Laboratory of Bio-Organic and Natural Products Chemistry and Collaborative Innovation Center of Chemistry for life Sciences, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Ling Ling Road, Shanghai 200032, China.
出版信息
J Am Chem Soc. 2015 Jun 3;137(21):6746-9. doi: 10.1021/jacs.5b03760. Epub 2015 May 18.
PMID:25938599
Abstract
The rhodium-catalyzed asymmetric hydroboration of α-arylenamides with BI-DIME as the chiral ligand and (Bpin)2 as the reagent yields for the first time a series of α-amino tertiary boronic esters in good yields and excellent enantioselectivities (up to 99% ee).
摘要
铑催化的α-芳烯酰胺的不对称硼氢化反应，使用 BI-DIME 作为手性配体和 (Bpin)2 作为试剂，首次以良好的收率和优异的对映选择性（高达 99%ee）得到一系列α-氨基叔硼酸酯。
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