Hahn Susanne A, Bellinghausen Iris, Trinschek Bettina, Becker Christian
Department of Dermatology, University Medical Center, Johannes Gutenberg-University , Mainz , Germany.
Front Immunol. 2015 Dec 14;6:623. doi: 10.3389/fimmu.2015.00623. eCollection 2015.
Regulatory T cells (Treg) control immune cell function as well as non-immunological processes. Their far-reaching regulatory activities suggest their functional manipulation as a means to sustainably and causally intervene with the course of diseases. Preclinical tools and strategies are however needed to further test and develop interventional strategies outside the human body. "Humanized" mouse models consisting of mice engrafted with human immune cells and tissues provide new tools to analyze human Treg ontogeny, immunobiology, and therapy. Here, we summarize the current state of humanized mouse models as a means to study human Treg function at the molecular level and to design strategies to harness these cells for therapeutic purposes.
调节性T细胞（Treg）控制免疫细胞功能以及非免疫过程。其广泛的调节活性表明可对其功能进行操控，以此作为可持续且有针对性地干预疾病进程的一种手段。然而，需要临床前工具和策略来进一步在人体外测试和开发干预策略。由植入人类免疫细胞和组织的小鼠构成的“人源化”小鼠模型为分析人类Treg的个体发生、免疫生物学及治疗提供了新工具。在此，我们总结人源化小鼠模型的当前状态，将其作为在分子水平研究人类Treg功能以及设计利用这些细胞用于治疗目的策略的一种手段。
