Ching Travers, Masaki Jayson, Weirather Jason, Garmire Lana X
Molecular Biosciences and Bioengineering Graduate Program, University of Hawaii at Manoa, Honolulu, HI 96822 USA ; Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI 96813 USA.
Laboratory of Immunology and Signal Transduction, Chaminade University of Honolulu, Honolulu, HI 96816 USA.
BioData Min. 2015 Dec 22;8:44. doi: 10.1186/s13040-015-0075-z. eCollection 2015.
Long intergenic non-coding RNAs (lincRNAs) represent one of the most mysterious RNA species encoded by the human genome. Thanks to next generation sequencing (NGS) technology and its applications, we have recently witnessed a surge in non-coding RNA research, including lincRNA research. Here, we summarize the recent advancement in genomics studies of lincRNAs. We review the emerging characteristics of lincRNAs, the experimental and computational approaches to identify lincRNAs, their known mechanisms of regulation, the computational methods and resources for lincRNA functional predictions, and discuss the challenges to understanding lincRNA comprehensively.
长链基因间非编码RNA（lincRNA）是人类基因组编码的最神秘的RNA种类之一。得益于新一代测序（NGS）技术及其应用，我们最近见证了非编码RNA研究的激增，包括lincRNA研究。在此，我们总结了lincRNA基因组学研究的最新进展。我们回顾了lincRNA的新特性、鉴定lincRNA的实验和计算方法、其已知的调控机制、lincRNA功能预测的计算方法和资源，并讨论了全面理解lincRNA所面临的挑战。
