Jiang Qinghua, Wang Jixuan, Wu Xiaoliang, Ma Rui, Zhang Tianjiao, Jin Shuilin, Han Zhijie, Tan Renjie, Peng Jiajie, Liu Guiyou, Li Yu, Wang Yadong
School of Life Science and Technology, Harbin Institute of Technology, Harbin, Heilongjiang 150001, China.
School of Software, Harbin Institute of Technology, Harbin, Heilongjiang 150001, China.
Nucleic Acids Res. 2015 Jan;43(Database issue):D193-6. doi: 10.1093/nar/gku1173. Epub 2014 Nov 15.
Long non-coding RNAs (lncRNAs) have emerged as critical regulators of genes at epigenetic, transcriptional and post-transcriptional levels, yet what genes are regulated by a specific lncRNA remains to be characterized. To assess the effects of the lncRNA on gene expression, an increasing number of researchers profiled the genome-wide or individual gene expression level change after knocking down or overexpressing the lncRNA. Herein, we describe a curated database named LncRNA2Target, which stores lncRNA-to-target genes and is publicly accessible at http://www.lncrna2target.org. A gene was considered as a target of a lncRNA if it is differentially expressed after the lncRNA knockdown or overexpression. LncRNA2Target provides a web interface through which its users can search for the targets of a particular lncRNA or for the lncRNAs that target a particular gene. Both search types are performed either by browsing a provided catalog of lncRNA names or by inserting lncRNA/target gene IDs/names in a search box.
长链非编码RNA（lncRNAs）已成为基因在表观遗传、转录和转录后水平的关键调节因子，但特定lncRNA调控哪些基因仍有待确定。为了评估lncRNA对基因表达的影响，越来越多的研究人员在敲低或过表达lncRNA后，分析了全基因组或单个基因的表达水平变化。在此，我们描述了一个名为LncRNA2Target的精选数据库，该数据库存储lncRNA与其靶基因的信息，可通过http://www.lncrna2target.org公开访问。如果一个基因在lncRNA敲低或过表达后差异表达，则该基因被视为lncRNA的靶标。LncRNA2Target提供了一个网络界面，用户可以通过该界面搜索特定lncRNA的靶标，或搜索靶向特定基因的lncRNA。这两种搜索类型都可以通过浏览提供的lncRNA名称目录，或在搜索框中插入lncRNA/靶基因ID/名称来执行。
