Gao Wei, Hu Tian-yuan, Guo Juan, Lv Dong-mei, Dai Zhu-bo, Zhou Yong-jin, Huang Lu-qi
Zhongguo Zhong Yao Za Zhi. 2015 Jul;40(13):2486-91.
Synthetic biology research methods which design and build a new artificial biological systems (medicinal plants or microorganisms system) with specific physiological functions through clarifying and simulating the basic law of the biosynthesis of active components of traditional Chinese medicine, is considered to be a potential method to produce an abundant resources of bioactive components. Tanshinones is a kind of diterpene quinone compounds with important pharmacological activities from traditional Chinese medicine Salvia miltiorrhiza. This article systematically introduced the research progress of the synthetic biology of S. miltiorrhiza, in order to provide references for studies on other terpenoid bioactive components of traditional Chinese medicines, and give new research strategies for the sustainable development of traditional Chinese medicine resources.
合成生物学研究方法通过阐明和模拟中药活性成分生物合成的基本规律，设计并构建具有特定生理功能的新型人工生物系统（药用植物或微生物系统），被认为是一种生产丰富生物活性成分资源的潜在方法。丹参酮是一种具有重要药理活性的二萜醌类化合物，来源于传统中药丹参。本文系统介绍了丹参合成生物学的研究进展，为其他中药萜类生物活性成分的研究提供参考，并为中药资源的可持续发展提供新的研究策略。
