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[丹参作为药用模式植物]

[Salvia miltiorrhiza as medicinal model plant].

作者信息

Song Jing-Yuan, Luo Hong-Mei, Li Chun-Fang, Sun Chao, Xu Jiang, Chen Shi-Lin

机构信息

Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China.

出版信息

Yao Xue Xue Bao. 2013 Jul;48(7):1099-106.

Abstract

Research on medicinal model organism is one of the core technologies to promote the modernization of traditional Chinese medicine (TCM). The research progress of Salvia miltiorrhiza as medicinal model plant is summarized in this paper. The genome of S. miltiorrhiza is small and its life cycle is short, as well as this plant can be stably genetically transformed. Because S. miltiorrhiza possesses the important medicinal and economic values, recently the transcriptome and genome of S. miltiorrhiza have been significantly recovered. The research prospect of S. miltiorrhiza as medicinal model plant in TCM was discussed, including biosynthesis of active components and their genetic regulation, relationship between quality of TCM and ecological environments, and selective breeding of good quality lines. Furthermore, as medicinal model plant, the construction of mutant library for S. miltiorrhiza, the genome map with high quality, and the functional genome should be investigated. Accompanying modern investigation of life sciences, the platform for medicinal model plant, S. miltiorrhiza, will be promoted to be established. It is important to develop the ethnopharmacology and new drugs around the world.

摘要

药用模式生物研究是推动中医药现代化的核心技术之一。本文综述了丹参作为药用模式植物的研究进展。丹参基因组小、生命周期短,且能进行稳定的遗传转化。由于丹参具有重要的药用和经济价值,近年来其转录组和基因组研究取得了显著进展。讨论了丹参作为中医药药用模式植物的研究前景,包括活性成分的生物合成及其遗传调控、中药质量与生态环境的关系以及优质品系的选育。此外,作为药用模式植物,还应开展丹参突变体库构建、高质量基因组图谱绘制及功能基因组研究。随着现代生命科学研究的深入,丹参药用模式植物平台将得到推动建立。这对于全球民族药理学和新药开发具有重要意义。

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