Wu T-W, Tsai F-P
Department of Pharmacy, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Taipei, Taiwan.
Drug Res (Stuttg). 2016 May;66(5):257-61. doi: 10.1055/s-0035-1569326. Epub 2015 Dec 23.
Iron deficiency anemia is an important public health issue, especially for infants, children, and women with menorrhagia. Oral iron supplements are the cheapest, safest, and most effective treatment. This study compared the therapeutic and side effects of ferrous and ferric in iron deficiency anemia.
This was a retrospective study on data collected between April 2012 and October 2013 for patients with iron deficiency anemia who continuously took oral ferric for over one month and then switched to oral ferrous due to poor therapeutic effects. The exclusion criteria were the use of other oral or injected iron preparations, erythropoietin, or vitamin B12.
A total of 41 participants were recruited. The average participant age was 44.76±16.89 years; most participants were females (95.1%; 39/41); the average daily dose of oral ferric (139.02±49.39 mg) was higher than that of ferrous (96.34±23.43 mg). Repeated measures: mixed model analyses were conducted to examine patients' clinical blood test values. The results showed that the mean blood test values for all patients significantly increased after switching to ferrous (p<0.01, with the exception of mean corpuscular hemoglobin). One patient experienced gastrointestinal discomfort and diarrhea after switching to ferrous.
This study found that blood test values improved after iron deficiency anemia female patients who displayed poor therapeutic effects with oral ferric switched to ferrous. Literature review showed that the risk for gastrointestinal problems with ferrous is higher than that with ferric. However, no significant difference was found in this study.
缺铁性贫血是一个重要的公共卫生问题，尤其对于婴儿、儿童以及月经过多的女性而言。口服铁剂补充是最便宜、最安全且最有效的治疗方法。本研究比较了亚铁和铁在缺铁性贫血治疗中的疗效及副作用。
这是一项回顾性研究，收集了2012年4月至2013年10月期间缺铁性贫血患者的数据，这些患者连续口服铁剂超过一个月，因治疗效果不佳后改用口服亚铁。排除标准为使用其他口服或注射铁剂、促红细胞生成素或维生素B12。
共招募了41名参与者。参与者的平均年龄为44.76±16.89岁；大多数参与者为女性（95.1%；39/41）；口服铁的平均每日剂量（139.02±49.39mg）高于亚铁（96.34±23.43mg）。重复测量：采用混合模型分析来检查患者的临床血液检测值。结果显示，改用亚铁后所有患者的平均血液检测值均显著升高（p<0.01，平均红细胞血红蛋白除外）。一名患者改用亚铁后出现胃肠道不适和腹泻。
本研究发现，口服铁治疗效果不佳的缺铁性贫血女性患者改用亚铁后血液检测值有所改善。文献综述表明，亚铁引起胃肠道问题的风险高于铁。然而，本研究未发现显著差异。
