化疗引起的恶心和呕吐对健康相关生活质量及资源利用的影响：一项系统综述。
Impact of chemotherapy-induced nausea and vomiting on health-related quality of life and resource utilization: A systematic review.
作者信息
Sommariva Silvia, Pongiglione Benedetta, Tarricone Rosanna
机构信息
Centre for Research on Health and Social Care Management (CERGAS), Milan, Italy.
Department of Medical Statistics, Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK.
出版信息
Crit Rev Oncol Hematol. 2016 Mar;99:13-36. doi: 10.1016/j.critrevonc.2015.12.001. Epub 2015 Dec 4.
BACKGROUND
Chemotherapy-induced nausea and vomiting (CINV) is a particularly distressing event for oncology patients. This review aims at analyzing the impact of CINV on Health-Related Quality of Life (QoL) and on the use of healthcare resources.
METHODS
A systematic search was conducted according to the PRISMA statement on MEDLINE, EMBASE and NHS EED.
RESULTS
Sixty-seven studies were included in the final selection. Despite the availability of numerous treatment options, CINV was found to have a strong impact on HRQoL of patients. Direct costs are particularly affected, but this result could be due to scarcity of studies assessing indirect costs.
CONCLUSIONS
Evidence supports the notion that CINV continues to have a negative impact on HRQoL of patients, even for those receiving moderately emetic chemotherapy. Further studies need also to collect data on the cost of CINV, particularly indirect costs, to ensure that decisions on use of healthcare resources are better supported.
背景
化疗引起的恶心和呕吐（CINV）对肿瘤患者来说是特别令人痛苦的事件。本综述旨在分析CINV对健康相关生活质量（QoL）和医疗资源使用的影响。
方法
根据PRISMA声明，在MEDLINE、EMBASE和NHS EED上进行了系统检索。
结果
最终纳入67项研究。尽管有多种治疗选择，但发现CINV对患者的健康相关生活质量有很大影响。直接成本受到的影响尤为明显，但这一结果可能是由于评估间接成本的研究较少。
结论
有证据支持这样一种观点，即CINV继续对患者的健康相关生活质量产生负面影响，即使对于那些接受中度致吐性化疗的患者也是如此。还需要进一步的研究来收集CINV的成本数据，特别是间接成本，以确保在医疗资源使用方面的决策能得到更好的支持。
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