Wang Xin, Fan Yue, Xiang Yijin, Zhang Shilong, Yang Yunke
Department of Integrative Medicine, Shanghai Geriatric Center, Shanghai, China.
Department of Integrative Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.
Transl Gastroenterol Hepatol. 2025 Apr 14;10:26. doi: 10.21037/tgh-24-35. eCollection 2025.
Chemotherapy-induced nausea and vomiting (CINV) significantly impact cancer patients' quality of life. Traditional pharmacological treatments often have limited effectiveness and can cause adverse effects. Acupuncture, a key practice in traditional Chinese medicine (TCM), shows promise as a complementary therapy for CINV. The purpose of this study was to explore the effects and underlying mechanisms of acupuncture in treating CINV.
We employed a multi-faceted approach to comprehensively explore the abnormal performances of CINV model and to elucidate the regulatory effects of acupuncture in treating CINV through the integration of 16S rRNA analysis, serum metabolomics, and network pharmacology.
Acupuncture significantly reduced kaolin consumption, mitigated anorexia, and attenuated body weight loss compared to the model group. Acupuncture was found to modulate the gut microbiota composition, enhancing beneficial taxa and reducing harmful ones. Serum metabolomic analysis revealed significant alterations in metabolic profiles, with acupuncture impacting various metabolites involved in pathways related to fatty acid biosynthesis, urea cycle, and amino acid metabolism. Spearman correlation analysis indicated a significant association between gut microbial taxa and serum metabolites. Furthermore, network pharmacology analysis identified key genes () and pathways (PI3K/Akt, neuroactive ligand-receptor interaction) associated with the anti-CINV effects of acupuncture. In conclusion, acupuncture holds promise in ameliorating CINV through its multifaceted impact on gut microbiota, serum metabolome, and molecular pathways.
Acupuncture was an adjunctive and important non-drug treatment for CINV, with the protective effects linked to the improvement of gut microbiota disruption and metabolic abnormalities.
化疗引起的恶心和呕吐（CINV）对癌症患者的生活质量有显著影响。传统药物治疗往往效果有限且会引起不良反应。针灸作为中医的一项关键疗法，显示出作为CINV辅助治疗方法的潜力。本研究的目的是探讨针灸治疗CINV的效果及潜在机制。
我们采用多方面的方法，通过整合16S rRNA分析、血清代谢组学和网络药理学，全面探究CINV模型的异常表现，并阐明针灸治疗CINV的调节作用。
与模型组相比，针灸显著减少高岭土摄入量，减轻厌食症状，并减轻体重减轻。发现针灸可调节肠道微生物群组成，增加有益菌群并减少有害菌群。血清代谢组学分析显示代谢谱有显著变化，针灸影响与脂肪酸生物合成、尿素循环和氨基酸代谢相关途径中的各种代谢物。Spearman相关性分析表明肠道微生物分类群与血清代谢物之间存在显著关联。此外，网络药理学分析确定了与针灸抗CINV作用相关的关键基因（）和途径（PI3K/Akt、神经活性配体-受体相互作用）。总之，针灸通过对肠道微生物群、血清代谢组和分子途径的多方面影响，有望改善CINV。
针灸是CINV的一种辅助且重要的非药物治疗方法，其保护作用与改善肠道微生物群紊乱和代谢异常有关。
