Yang Shih-Neng, Sun Shung-Shung, Zhang Geoffrey, Chou Kuei-Ting, Lo Shih-Wen, Chiou Yu-Rou, Li Fang-Jing, Huang Tzung-Chi
Department of Biomedical Imaging and Radiological Science, China Medical University, No. 91, Hsueh-Shih Road, Taichung, 40402, Taiwan.
Department of Radiation Oncology, China Medical University Hospital, No. 2, Yude Road, Taichung, 40447, Taiwan.
Biomed Eng Online. 2015 Dec 23;14:119. doi: 10.1186/s12938-015-0117-2.
A new non-linear approach was applied to calculate the left ventricular ejection fraction (LVEF) using multigated acquisition (MUGA) images.
In this study, 50 patients originally for the estimation of the percentage of LVEF to monitor the effects of various cardiotoxic drugs in chemotherapy were retrospectively selected. All patients had both MUGA and echocardiography examinations (ECHO LVEF) at the same time. Mutual information (MI) theory was utilized to calculate the LVEF using MUGA imaging (MUGA MI).
MUGA MI estimation was significantly different from MUGA LVEF and ECHO LVEF, respectively (p < 0.005). The higher repeatability for MUGA MI can be observed in the figure by the higher correlation coefficient for MUGA MI (r = 0.95) compared with that of MUGA LVEF (r = 0.80). Again, the reproducibility was better for MUGA MI (r = 0.90, 0.92) than MUGA LVEF (r = 0.77, 0.83). The higher correlation coefficients were obtained between proposed MUGA MI and ECHO LVEF compared to that between the conventional MUGA LVEF and ECHO LVEF.
MUGA image with the aid of MI is promising to be more interchangeable LVEF to ECHO LVEF measurement as compared with the conventional approach on MUGA image.
应用一种新的非线性方法，利用多门控采集（MUGA）图像计算左心室射血分数（LVEF）。
本研究回顾性选取了50例最初用于评估LVEF百分比以监测各种心脏毒性药物化疗效果的患者。所有患者同时进行了MUGA和超声心动图检查（ECHO LVEF）。利用互信息（MI）理论，通过MUGA成像计算LVEF（MUGA MI）。
MUGA MI估计值分别与MUGA LVEF和ECHO LVEF有显著差异（p < 0.005）。通过与MUGA LVEF（r = 0.80）相比，MUGA MI具有更高的相关系数（r = 0.95），可以在图中观察到MUGA MI具有更高的重复性。再次，MUGA MI的可重复性（r = 0.90，0.92）优于MUGA LVEF（r = 0.77，0.83）。与传统的MUGA LVEF和ECHO LVEF之间相比，所提出的MUGA MI与ECHO LVEF之间获得了更高的相关系数。
与传统的MUGA图像方法相比，借助MI的MUGA图像有望在LVEF测量方面更易于与ECHO LVEF测量相互转换。
